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Outcomes of Solid Organ Transplant Recipients With Preexisting Malignancies in Remission

Overview of attention for article published in Transplantation, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 5,655)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
24 news outlets
twitter
18 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
18 Mendeley
Title
Outcomes of Solid Organ Transplant Recipients With Preexisting Malignancies in Remission
Published in
Transplantation, March 2017
DOI 10.1097/tp.0000000000001192
Pubmed ID
Authors

Sergio A. Acuna, Johnny W. Huang, Corinne Daly, Prakesh S. Shah, S. Joseph Kim, Nancy N. Baxter

Abstract

Solid organ transplant recipients (SOTR) with a pretransplant malignancy (PTM) are at increased risk for cancer recurrence. However, it is unclear whether differences in survival and incidence of posttransplant de novo malignancies exist between recipients with PTM and those without PTM. We designed a systematic review to synthesize all available evidence assessing these outcomes. A systematic search was performed in MEDLINE, EMBASE, and Cochrane Library to identify studies comparing the following outcomes in SOTR by PTM status: (1) all-cause mortality, (2) cancer-specific mortality, and (3) incidence of posttransplant de novo malignancy. Risk of bias was assessed using the Newcastle-Ottawa Scale. Thirty-two cohort studies were included. Recipients with PTM were at increased risk of all-cause mortality compared to recipients without PTM (pooled hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.27-1.81). Similarly, recipients with PTM were 3 times more likely to die of cancer (pooled HR, 3.13; 95% CI, 2.29-4.27). The pooled HR for developing posttransplant de novo malignancy was also increased (HR, 1.92; 95% CI, 1.52-2.42). The association of all-cause mortality and SOTR with PTM did not vary by transplanted organ. Pretransplant malignancy is associated with increased risk of all cause-mortality, cancer-specific mortality and of developing de novo malignancies after transplantation compared with those without PTM. These results reaffirm the need for careful selection of transplant recipients with PTM. Tailored screening and management strategies should be developed for this group of patients.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 28%
Student > Ph. D. Student 3 17%
Unspecified 2 11%
Student > Master 2 11%
Student > Doctoral Student 1 6%
Other 4 22%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 12 67%
Unspecified 3 17%
Biochemistry, Genetics and Molecular Biology 1 6%
Arts and Humanities 1 6%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 179. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2017.
All research outputs
#77,979
of 13,632,082 outputs
Outputs from Transplantation
#2
of 5,655 outputs
Outputs of similar age
#3,077
of 260,530 outputs
Outputs of similar age from Transplantation
#1
of 71 outputs
Altmetric has tracked 13,632,082 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,655 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,530 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.