@JessieChimni @Astrox1111 TNFAIP3 (that encodes a protein called A20) has anti-apoptotic and anti-inflammatory properties. It also promotes beta-cell survival and protects against islet graft rejection, at least preclinically https://t.co/PmCea0DR0w
A20 is an immune tolerance factor that can determine islet transplantoutcomes. published as: https://t.co/48xXrkXBLk @JCI_insight #biorxiv
Expression of ubiquitin editing enzyme A20 can determine islet transplant outcomes https://t.co/sKJFbLiCSI @GarvanInstitute #inflammation #transplantation https://t.co/2EVdzkNfVE
“Therapeutic administration of A20 raises inflammatory signalling thresholds to favour immune tolerance and promotes #islet allogeneic survival” @JCI_insight https://t.co/BNTRZuYpTh