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High-resolution computed tomography findings in young infants with cystic fibrosis detected by newborn screening

Overview of attention for article published in Clinics, October 2019
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Title
High-resolution computed tomography findings in young infants with cystic fibrosis detected by newborn screening
Published in
Clinics, October 2019
DOI 10.6061/clinics/2019/e1399
Pubmed ID
Authors

Renata Wrobel Folescu Cohen, Tânia Wrobel Folescu, Marcia Cristina Bastos Boechat, Vania Matos Fonseca, Elizabeth Andrade Marques, Robson Souza Leão

Abstract

High-resolution computed tomography (HRCT) allows the early detection of pathological changes in the lung structure, and reproducible scoring systems can be used to quantify chest computed tomography (CT) findings in patients with cystic fibrosis (CF). The aim of the study was to describe early HRCT findings according to a validated scoring system in infants with CF diagnosed by newborn screening (NBS). This cross-sectional study included infants with CF diagnosed by NBS who were born between January 2013 and January 2017 and who underwent HRCT scanning within the first year after diagnosis when they were clinically stable. The CT scans were evaluated using the modified Bhalla score. Thirty-two subjects underwent HRCT scanning. The mean total-modified Bhalla score was 3.6±2.1, and 93.8% of the scans were abnormal. Pseudomonas aeruginosa airway colonization was associated with increased modified Bhalla score values. Bronchial wall thickening was the most common feature (90.6%), followed by bronchial collapse/consolidation (59.4%), mosaic attenuation/perfusion (50%), bronchiectasis (37.5%) and mucus plugging (15.6%). Bronchial wall thickening was diffuse in most of the patients. A substantial proportion of infants diagnosed with CF after detection by NBS already showed evidence of lung disease. P. aeruginosa colonization was associated with increased Bhalla scores, highlighting the importance of this CF pathogen in early structural lung disease. The presence of bronchial wall thickening at such a young age may reflect the presence of airway inflammatory processes. The detection and quantification of structural abnormalities with the modified Bhalla score may aid in the identification of lung disease before it is clinically apparent.

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Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 18%
Professor 1 9%
Other 1 9%
Researcher 1 9%
Student > Postgraduate 1 9%
Other 0 0%
Unknown 5 45%
Readers by discipline Count As %
Medicine and Dentistry 3 27%
Veterinary Science and Veterinary Medicine 1 9%
Unknown 7 64%