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c-Jun N-terminal kinase-dependent apoptotic photocytotoxicity of solvent exchange-prepared curcumin nanoparticles

Overview of attention for article published in Biomedical Microdevices, April 2016
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Title
c-Jun N-terminal kinase-dependent apoptotic photocytotoxicity of solvent exchange-prepared curcumin nanoparticles
Published in
Biomedical Microdevices, April 2016
DOI 10.1007/s10544-016-0062-2
Pubmed ID
Authors

Verica Paunovic, Biljana Ristic, Zoran Markovic, Biljana Todorovic-Markovic, Milica Kosic, Jovana Prekodravac, Tamara Kravic-Stevovic, Tamara Martinovic, Matej Micusik, Zdeno Spitalsky, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic

Abstract

Indian spice curcumin is known for its anticancer properties, but the anticancer mechanisms of nanoparticulate curcumin have not been completely elucidated. We here investigated the in vitro anticancer effect of blue light (470 nm, 1 W)-irradiated curcumin nanoparticles prepared by tetrahydrofuran/water solvent exchange, using U251 glioma, B16 melanoma, and H460 lung cancer cells as targets. The size of curcumin nanocrystals was approximately 250 nm, while photoexcitation induced their oxidation and partial agglomeration. Although cell membrane in the absence of light was almost impermeable to curcumin nanoparticles, photoexcitation stimulated their internalization. While irradiation with blue light (1-8 min) or nanocurcumin (1.25-10 μg/ml) alone was only marginally toxic to tumor cells, photoexcited nanocurcumin displayed a significant cytotoxicity depending both on the irradiation time and nanocurcumin concentration. Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. Accordingly, pharmacologial inhibition of JNK and caspase activity rescued cancer cells from photoexcited nanocurcumin. On the other hand, antioxidant treatment did not reduce photocytotoxicity of nanocurcumin, arguing against the involvement of oxidative stress. By demonstrating the ability of photoexcited nanocurcumin to induce oxidative-stress independent, JNK- and caspase-dependent apoptosis, our results support its further investigation in cancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Master 8 19%
Student > Doctoral Student 4 9%
Professor > Associate Professor 3 7%
Student > Ph. D. Student 3 7%
Other 7 16%
Unknown 10 23%
Readers by discipline Count As %
Materials Science 6 14%
Agricultural and Biological Sciences 5 12%
Medicine and Dentistry 5 12%
Chemistry 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Other 8 19%
Unknown 12 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2016.
All research outputs
#10,916,731
of 12,319,016 outputs
Outputs from Biomedical Microdevices
#408
of 483 outputs
Outputs of similar age
#228,833
of 274,752 outputs
Outputs of similar age from Biomedical Microdevices
#5
of 7 outputs
Altmetric has tracked 12,319,016 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 483 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,752 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.