Title |
Does Vitamin E Prevent or Promote Cancer?
|
---|---|
Published in |
Cancer Prevention Research, May 2012
|
DOI | 10.1158/1940-6207.capr-12-0045 |
Pubmed ID | |
Authors |
Chung S. Yang, Nanjoo Suh, Ah-Ng Tony Kong |
Abstract |
The cancer preventive activity of vitamin E has been suggested by many epidemiologic studies. However, several recent large-scale human trials with α-tocopherol, the most commonly recognized and used form of vitamin E, failed to show a cancer preventive effect. The recently finished follow-up of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) even showed higher prostate cancer incidence in subjects who took α-tocopherol supplementation. The scientific community and the general public are faced with a question: "Does vitamin E prevent or promote cancer?" Our recent results in animal models have shown the cancer preventive activity of γ- and δ-tocopherols as well as a naturally occurring mixture of tocopherols, and the lack of cancer preventive activity by α-tocopherol. On the basis of these results as well as information from the literature, we suggest that vitamin E, as ingested in the diet or in supplements that are rich in γ- and δ-tocopherols, is cancer preventive; whereas supplementation with high doses of α-tocopherol is not. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 25% |
Canada | 2 | 8% |
Chile | 1 | 4% |
Mexico | 1 | 4% |
United Kingdom | 1 | 4% |
Netherlands | 1 | 4% |
Australia | 1 | 4% |
Unknown | 11 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 71% |
Practitioners (doctors, other healthcare professionals) | 5 | 21% |
Scientists | 2 | 8% |
Mendeley readers
Geographical breakdown
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---|---|---|
United States | 2 | 2% |
Spain | 1 | <1% |
Singapore | 1 | <1% |
Costa Rica | 1 | <1% |
Unknown | 113 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 17% |
Researcher | 16 | 14% |
Student > Master | 15 | 13% |
Student > Ph. D. Student | 10 | 8% |
Other | 9 | 8% |
Other | 22 | 19% |
Unknown | 26 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 24% |
Agricultural and Biological Sciences | 20 | 17% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Nursing and Health Professions | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 14 | 12% |
Unknown | 32 | 27% |