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Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing

Overview of attention for article published in Military Medical Research, October 2019
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Title
Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
Published in
Military Medical Research, October 2019
DOI 10.1186/s40779-019-0222-9
Pubmed ID
Authors

Jing-jing Ji, Jie Fan

Abstract

The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Bachelor 3 10%
Student > Doctoral Student 2 7%
Student > Ph. D. Student 2 7%
Professor 2 7%
Other 3 10%
Unknown 13 43%
Readers by discipline Count As %
Immunology and Microbiology 6 20%
Medicine and Dentistry 3 10%
Veterinary Science and Veterinary Medicine 1 3%
Business, Management and Accounting 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 7%
Unknown 16 53%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2019.
All research outputs
#19,954,338
of 25,387,668 outputs
Outputs from Military Medical Research
#328
of 443 outputs
Outputs of similar age
#271,268
of 375,851 outputs
Outputs of similar age from Military Medical Research
#4
of 10 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 443 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.