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The Alkali Metal Ions: Their Role for Life

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Cover of 'The Alkali Metal Ions: Their Role for Life'

Table of Contents

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    Book Overview
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    Chapter 1 Bioinorganic Chemistry of the Alkali Metal Ions
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    Chapter 2 The Alkali Metal Ions: Their Role for Life
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    Chapter 3 The Alkali Metal Ions: Their Role for Life
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    Chapter 4 Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies
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    Chapter 5 Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
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    Chapter 6 Sodium and Potassium Interactions with Nucleic Acids
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    Chapter 7 Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
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    Chapter 8 Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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    Chapter 9 Roles and Transport of Sodium and Potassium in Plants.
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    Chapter 10 Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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    Chapter 11 Sodium as Coupling Cation in Respiratory Energy Conversion
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    Chapter 12 The Alkali Metal Ions: Their Role for Life
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    Chapter 13 Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
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    Chapter 14 Bioinspired Artificial Sodium and Potassium Ion Channels
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    Chapter 15 The Alkali Metal Ions: Their Role for Life
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    Chapter 16 Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Attention for Chapter 16: Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
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Chapter title
Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Chapter number 16
Book title
The Alkali Metal Ions: Their Role for Life
Published in
Metal ions in life sciences, January 2016
DOI 10.1007/978-3-319-21756-7_16
Pubmed ID
Book ISBNs
978-3-31-921755-0, 978-3-31-921756-7

Yonghwang Ha, Jeong A Jeong, Youngsam Kim, David G. Churchill, Ha, Yonghwang, Jeong, Jeong A, Kim, Youngsam, Churchill, David G.


Alkali metals, especially sodium and potassium, are plentiful and vital in biological systems. They take on important roles in health and disease. Such roles include the regulation of homeostasis, osmosis, blood pressure, electrolytic equilibria, and electric current. However, there is a limit to our present understanding; the ions have a great ability and capacity for action in health and disease, much greater than our current understanding. For the regulation of physiological homeostasis, there is a crucial regulator (renin-angiotensin system, RAS), found at both peripheral and central levels. Misregulation of the Na(+)-K(+) pump, and sodium channels in RAS are important for the understanding of disease progression, hypertension, diabetes, and neurodegenerative diseases, etc. In particular, RAS displays direct or indirect interaction important to Parkinson's disease (PD). In this chapter, the relationship between the regulation of sodium/potassium concentration and PD was sought. In addition, some recent biochemical and clinical findings are also discussed that help describe sodium and potassium in the context of traumatic brain injury (TBI). TBI is caused from the heavy striking of the head; this strongly affects ion flux in the affected tissue (brain) and damages cellular regulation systems. Thus, inappropriate concentrations of ions (hyper- and hyponatremia, and hyper- and hypokalemia) will perturb homeostasis giving rise to important and far reaching effects. These changes also impact osmotic pressure and the concentration of other metal ions, such as the calcium(II) ion.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 17%
Student > Doctoral Student 6 13%
Student > Ph. D. Student 5 11%
Researcher 4 9%
Student > Master 4 9%
Other 9 20%
Unknown 10 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 17%
Medicine and Dentistry 8 17%
Nursing and Health Professions 6 13%
Neuroscience 4 9%
Social Sciences 3 7%
Other 7 15%
Unknown 10 22%