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The Alkali Metal Ions: Their Role for Life

Overview of attention for book
Cover of 'The Alkali Metal Ions: Their Role for Life'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Bioinorganic Chemistry of the Alkali Metal Ions
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    Chapter 2 The Alkali Metal Ions: Their Role for Life
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    Chapter 3 The Alkali Metal Ions: Their Role for Life
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    Chapter 4 Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies
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    Chapter 5 Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
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    Chapter 6 Sodium and Potassium Interactions with Nucleic Acids
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    Chapter 7 Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
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    Chapter 8 Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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    Chapter 9 Roles and Transport of Sodium and Potassium in Plants.
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    Chapter 10 Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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    Chapter 11 Sodium as Coupling Cation in Respiratory Energy Conversion
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    Chapter 12 The Alkali Metal Ions: Their Role for Life
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    Chapter 13 Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
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    Chapter 14 Bioinspired Artificial Sodium and Potassium Ion Channels
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    Chapter 15 The Alkali Metal Ions: Their Role for Life
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    Chapter 16 Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Attention for Chapter 8: Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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About this Attention Score

  • Among the highest-scoring outputs from this source (#48 of 135)
  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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Chapter title
Sodium and Potassium Ions in Proteins and Enzyme Catalysis
Chapter number 8
Book title
The Alkali Metal Ions: Their Role for Life
Published in
Metal ions in life sciences, January 2016
DOI 10.1007/978-3-319-21756-7_8
Pubmed ID
Book ISBNs
978-3-31-921755-0, 978-3-31-921756-7

Milan Vašák, Joachim Schnabl, Vašák, Milan, Schnabl, Joachim


The group I alkali metal ions Na(+) and K(+) are ubiquitous components of biological fluids that surround biological macromolecules. They play important roles other than being nonspecific ionic buffering agents or mediators of solute exchange and transport. Molecular evolution and regulated high intracellular and extracellular M(+) concentrations led to incorporation of selective Na(+) and K(+) binding sites into enzymes to stabilize catalytic intermediates or to provide optimal positioning of substrates. The mechanism of M(+) activation, as derived from kinetic studies along with structural analysis, has led to the classification of cofactor-like (type I) or allosteric effector (type II) activated enzymes. In the type I mechanism substrate anchoring to the enzyme active site is mediated by M(+), often acting in tandem with a divalent cation like Mg(2+), Mn(2+) or Zn(2+). In the allosteric type II mechanism, M(+) binding enhances enzyme activity through conformational transitions triggered upon binding to a distant site. In this chapter, following the discussion of the coordination chemistry of Na(+) and K(+) ions and the structural features responsible for the metal binding site selectivity in M(+)-activated enzymes, well-defined examples of M(+)-activated enzymes are used to illustrate the structural basis for type I and type II activation by Na(+) and K(+).

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Researcher 4 15%
Student > Ph. D. Student 4 15%
Student > Bachelor 3 11%
Professor 1 4%
Other 3 11%
Unknown 6 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 30%
Environmental Science 4 15%
Agricultural and Biological Sciences 4 15%
Chemistry 3 11%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2021.
All research outputs
of 23,043,346 outputs
Outputs from Metal ions in life sciences
of 135 outputs
Outputs of similar age
of 394,754 outputs
Outputs of similar age from Metal ions in life sciences
of 28 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 135 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.