Chapter title |
Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
|
---|---|
Chapter number | 13 |
Book title |
The Alkali Metal Ions: Their Role for Life
|
Published in |
Metal ions in life sciences, January 2016
|
DOI | 10.1007/978-3-319-21756-7_13 |
Pubmed ID | |
Book ISBNs |
978-3-31-921755-0, 978-3-31-921756-7
|
Authors |
Hideki Sakai, Takuto Fujii, Noriaki Takeguchi, Sakai, Hideki, Fujii, Takuto, Takeguchi, Noriaki |
Abstract |
As a physiological phenomenon, acid secretion from the stomach was known already at least in the 17th century. But its mechanism was elucidated in more recent times only. At the end of the 20th century, gastric H(+)/K(+)-ATPase in the parietal cells was found to be responsible for a final step of H(+) secretion in these cells. In this century, several Cl(-)-transporting proteins for gastric acid (hydrochloric acid; HCl) secretion have been found. As inhibitors of gastric acid secretion, histamine H2 receptor antagonists (H2 blockers) were developed in the 1970's. This discovery brought a great benefit; that is, peptic ulcers became treatable by administration of a drug. In 1980's, proton pump inhibitors (PPIs) were developed. The target of PPIs is gastric H(+)/K(+)-ATPase and the PPIs exert generally more potent effects compared with H2 blockers. Most recently, several K(+)-competitive inhibitors of the ATPase are being developed. Here, we introduce gastric H(+)/K(+)-ATPase and its related proteins for gastric acid secretion, and several gastric diseases and their treatment by medicines. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 3 | 14% |
Student > Master | 3 | 14% |
Professor > Associate Professor | 2 | 9% |
Student > Bachelor | 2 | 9% |
Lecturer > Senior Lecturer | 1 | 5% |
Other | 3 | 14% |
Unknown | 8 | 36% |
Readers by discipline | Count | As % |
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Unspecified | 3 | 14% |
Medicine and Dentistry | 3 | 14% |
Agricultural and Biological Sciences | 2 | 9% |
Immunology and Microbiology | 2 | 9% |
Chemistry | 2 | 9% |
Other | 2 | 9% |
Unknown | 8 | 36% |