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The zinc spark is an inorganic signature of human egg activation

Overview of attention for article published in Scientific Reports, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
37 news outlets
blogs
1 blog
twitter
205 tweeters
facebook
68 Facebook pages
googleplus
12 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
114 Mendeley
Title
The zinc spark is an inorganic signature of human egg activation
Published in
Scientific Reports, April 2016
DOI 10.1038/srep24737
Pubmed ID
Authors

Francesca E. Duncan, Emily L. Que, Nan Zhang, Eve C. Feinberg, Thomas V. O’Halloran, Teresa K. Woodruff

Abstract

Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation methods, as expected, induced rises in intracellular calcium levels and also triggered the coordinated release of zinc into the extracellular space in a prominent "zinc spark." The ability of the gamete to mount a zinc spark response was meiotic-stage dependent. Moreover, chelation of intracellular zinc alone was sufficient to induce cell cycle resumption and transition of a meiotic cell into a mitotic one. Together, these results demonstrate critical functions for zinc dynamics and establish the zinc spark as an extracellular marker of early human development.

Twitter Demographics

The data shown below were collected from the profiles of 205 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Colombia 1 <1%
Unknown 112 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 29%
Student > Bachelor 15 13%
Researcher 14 12%
Student > Master 12 11%
Student > Doctoral Student 8 7%
Other 19 17%
Unknown 13 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 24%
Agricultural and Biological Sciences 21 18%
Medicine and Dentistry 16 14%
Chemistry 13 11%
Engineering 7 6%
Other 13 11%
Unknown 17 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 491. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2020.
All research outputs
#22,187
of 15,378,024 outputs
Outputs from Scientific Reports
#336
of 79,540 outputs
Outputs of similar age
#815
of 265,428 outputs
Outputs of similar age from Scientific Reports
#19
of 3,116 outputs
Altmetric has tracked 15,378,024 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 79,540 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,428 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 3,116 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.