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The zinc spark is an inorganic signature of human egg activation

Overview of attention for article published in Scientific Reports, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
37 news outlets
blogs
1 blog
twitter
204 tweeters
facebook
68 Facebook pages
googleplus
12 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
123 Mendeley
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Title
The zinc spark is an inorganic signature of human egg activation
Published in
Scientific Reports, April 2016
DOI 10.1038/srep24737
Pubmed ID
Authors

Francesca E. Duncan, Emily L. Que, Nan Zhang, Eve C. Feinberg, Thomas V. O’Halloran, Teresa K. Woodruff

Abstract

Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation methods, as expected, induced rises in intracellular calcium levels and also triggered the coordinated release of zinc into the extracellular space in a prominent "zinc spark." The ability of the gamete to mount a zinc spark response was meiotic-stage dependent. Moreover, chelation of intracellular zinc alone was sufficient to induce cell cycle resumption and transition of a meiotic cell into a mitotic one. Together, these results demonstrate critical functions for zinc dynamics and establish the zinc spark as an extracellular marker of early human development.

Twitter Demographics

The data shown below were collected from the profiles of 204 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Colombia 1 <1%
Unknown 121 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 28%
Student > Bachelor 16 13%
Researcher 15 12%
Student > Master 13 11%
Student > Doctoral Student 8 7%
Other 20 16%
Unknown 17 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 24%
Agricultural and Biological Sciences 22 18%
Medicine and Dentistry 16 13%
Chemistry 14 11%
Engineering 7 6%
Other 13 11%
Unknown 21 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 492. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2020.
All research outputs
#24,111
of 15,937,237 outputs
Outputs from Scientific Reports
#372
of 83,152 outputs
Outputs of similar age
#826
of 266,018 outputs
Outputs of similar age from Scientific Reports
#20
of 3,131 outputs
Altmetric has tracked 15,937,237 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,152 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,018 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 3,131 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.