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Common variants at 12q14 and 12q24 are associated with hippocampal volume

Overview of attention for article published in Nature Genetics, April 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
1 news outlet
blogs
5 blogs
twitter
12 tweeters

Citations

dimensions_citation
179 Dimensions

Readers on

mendeley
240 Mendeley
citeulike
1 CiteULike
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Title
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Published in
Nature Genetics, April 2012
DOI 10.1038/ng.2237
Pubmed ID
Abstract

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7). In two additional samples (n = 2,318), associations were replicated at 12q14 within MSRB3-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10(-11)) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 × 10(-11)). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10(-7)) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10(-7)); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n = 1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 3%
United Kingdom 4 2%
Netherlands 3 1%
Brazil 1 <1%
Sweden 1 <1%
Australia 1 <1%
Germany 1 <1%
Unknown 221 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 51 21%
Student > Ph. D. Student 40 17%
Professor > Associate Professor 25 10%
Student > Master 19 8%
Other 18 8%
Other 62 26%
Unknown 25 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 20%
Medicine and Dentistry 43 18%
Biochemistry, Genetics and Molecular Biology 27 11%
Psychology 27 11%
Neuroscience 23 10%
Other 28 12%
Unknown 44 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2018.
All research outputs
#405,267
of 14,996,206 outputs
Outputs from Nature Genetics
#983
of 6,387 outputs
Outputs of similar age
#2,479
of 124,753 outputs
Outputs of similar age from Nature Genetics
#4
of 87 outputs
Altmetric has tracked 14,996,206 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,387 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,753 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.