Title |
Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes
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Published in |
BMC Ecology and Evolution, October 2009
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DOI | 10.1186/1471-2148-9-249 |
Pubmed ID | |
Authors |
Eve Gazave, Pascal Lapébie, Gemma S Richards, Frédéric Brunet, Alexander V Ereskovsky, Bernard M Degnan, Carole Borchiellini, Michel Vervoort, Emmanuelle Renard |
Abstract |
Of the 20 or so signal transduction pathways that orchestrate cell-cell interactions in metazoans, seven are involved during development. One of these is the Notch signalling pathway which regulates cellular identity, proliferation, differentiation and apoptosis via the developmental processes of lateral inhibition and boundary induction. In light of this essential role played in metazoan development, we surveyed a wide range of eukaryotic genomes to determine the origin and evolution of the components and auxiliary factors that compose and modulate this pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | <1% |
Brazil | 3 | <1% |
France | 2 | <1% |
Spain | 2 | <1% |
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Sweden | 1 | <1% |
Australia | 1 | <1% |
Russia | 1 | <1% |
Other | 3 | <1% |
Unknown | 343 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 91 | 25% |
Researcher | 67 | 18% |
Student > Bachelor | 40 | 11% |
Student > Master | 35 | 10% |
Professor | 19 | 5% |
Other | 54 | 15% |
Unknown | 57 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 159 | 44% |
Biochemistry, Genetics and Molecular Biology | 97 | 27% |
Immunology and Microbiology | 8 | 2% |
Medicine and Dentistry | 8 | 2% |
Engineering | 5 | 1% |
Other | 21 | 6% |
Unknown | 65 | 18% |