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Schizophrenia interactome with 504 novel protein–protein interactions

Overview of attention for article published in npj Schizophrenia, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
65 news outlets
blogs
3 blogs
twitter
68 tweeters
facebook
14 Facebook pages
wikipedia
1 Wikipedia page
googleplus
6 Google+ users

Readers on

mendeley
68 Mendeley
Title
Schizophrenia interactome with 504 novel protein–protein interactions
Published in
npj Schizophrenia, April 2016
DOI 10.1038/npjschz.2016.12
Pubmed ID
Authors

Madhavi K Ganapathiraju, Mohamed Thahir, Adam Handen, Saumendra N Sarkar, Robert A Sweet, Vishwajit L Nimgaonkar, Christine E Loscher, Eileen M Bauer, Srilakshmi Chaparala, Ganapathiraju, Madhavi K, Thahir, Mohamed, Handen, Adam, Sarkar, Saumendra N, Sweet, Robert A, Nimgaonkar, Vishwajit L, Loscher, Christine E, Bauer, Eileen M, Chaparala, Srilakshmi

Abstract

Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein interactions (PPIs) are unknown for many of the liability genes. We developed a computational model to discover PPIs, which is found to be highly accurate according to computational evaluations and experimental validations of selected PPIs. We present here, 365 novel PPIs of liability genes identified by the SZ Working Group of the Psychiatric Genomics Consortium (PGC). Seventeen genes that had no previously known interactions have 57 novel interactions by our method. Among the new interactors are 19 drug targets that are targeted by 130 drugs. In addition, we computed 147 novel PPIs of 25 candidate genes investigated in the pre-GWAS era. While there is little overlap between the GWAS genes and the pre-GWAS genes, the interactomes reveal that they largely belong to the same pathways, thus reconciling the apparent disparities between the GWAS and prior gene association studies. The interactome including 504 novel PPIs overall, could motivate other systems biology studies and trials with repurposed drugs. The PPIs are made available on a webserver, called Schizo-Pi at http://severus.dbmi.pitt.edu/schizo-pi with advanced search capabilities.

Twitter Demographics

The data shown below were collected from the profiles of 68 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 2 3%
Australia 1 1%
United Kingdom 1 1%
Denmark 1 1%
Poland 1 1%
United States 1 1%
Czech Republic 1 1%
Netherlands 1 1%
Unknown 59 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 29%
Researcher 16 24%
Student > Bachelor 8 12%
Student > Master 8 12%
Professor 3 4%
Other 11 16%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 41%
Biochemistry, Genetics and Molecular Biology 12 18%
Neuroscience 7 10%
Computer Science 5 7%
Medicine and Dentistry 5 7%
Other 9 13%
Unknown 2 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 590. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2017.
All research outputs
#5,902
of 8,403,326 outputs
Outputs from npj Schizophrenia
#2
of 85 outputs
Outputs of similar age
#559
of 272,660 outputs
Outputs of similar age from npj Schizophrenia
#1
of 5 outputs
Altmetric has tracked 8,403,326 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,660 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them