Title |
Treatment for mitochondrial disorders
|
---|---|
Published in |
Cochrane database of systematic reviews, April 2012
|
DOI | 10.1002/14651858.cd004426.pub3 |
Pubmed ID | |
Authors |
Gerald Pfeffer, Kari Majamaa, Douglass M Turnbull, David Thorburn, Patrick F Chinnery |
Abstract |
Mitochondrial respiratory chain disorders are the most prevalent group of inherited neurometabolic diseases. They present with central and peripheral neurological features usually in association with other organ involvement including the eye, the heart, the liver, and kidneys, diabetes mellitus and sensorineural deafness. Current treatment is largely supportive and the disorders progress relentlessly causing significant morbidity and premature death. Vitamin supplements, pharmacological agents and exercise therapy have been used in isolated cases and small clinical trials, but the efficacy of these interventions is unclear. The first review was carried out in 2003, and identified six clinical trials. This major update was carried out to identify new studies and grade the original studies for potential bias in accordance with revised Cochrane Collaboration guidelines. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
Netherlands | 1 | 14% |
United Kingdom | 1 | 14% |
Japan | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
United Kingdom | 3 | <1% |
Germany | 2 | <1% |
Ireland | 1 | <1% |
Switzerland | 1 | <1% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Unknown | 654 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 95 | 14% |
Researcher | 85 | 13% |
Student > Ph. D. Student | 77 | 12% |
Student > Bachelor | 76 | 11% |
Student > Postgraduate | 37 | 6% |
Other | 128 | 19% |
Unknown | 168 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 193 | 29% |
Nursing and Health Professions | 58 | 9% |
Agricultural and Biological Sciences | 51 | 8% |
Biochemistry, Genetics and Molecular Biology | 50 | 8% |
Neuroscience | 22 | 3% |
Other | 97 | 15% |
Unknown | 195 | 29% |