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Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Overview of attention for article published in Science, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
15 news outlets
blogs
3 blogs
twitter
125 tweeters
facebook
1 Facebook page
googleplus
5 Google+ users

Readers on

mendeley
606 Mendeley
citeulike
3 CiteULike
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Title
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Published in
Science, April 2016
DOI 10.1126/science.aad8852
Pubmed ID
Authors

Simone S. Li, Ana Zhu, Vladimir Benes, Paul I. Costea, Rajna Hercog, Falk Hildebrand, Jaime Huerta-Cepas, Max Nieuwdorp, Jarkko Salojärvi, Anita Y. Voigt, Georg Zeller, Shinichi Sunagawa, Willem M. de Vos, Peer Bork

Abstract

Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profiles of 125 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 606 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 2%
Denmark 5 <1%
Germany 3 <1%
Canada 3 <1%
United Kingdom 2 <1%
New Zealand 1 <1%
Belgium 1 <1%
Switzerland 1 <1%
China 1 <1%
Other 3 <1%
Unknown 573 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 132 22%
Researcher 128 21%
Student > Master 69 11%
Student > Bachelor 37 6%
Other 28 5%
Other 111 18%
Unknown 101 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 160 26%
Biochemistry, Genetics and Molecular Biology 101 17%
Immunology and Microbiology 72 12%
Medicine and Dentistry 69 11%
Environmental Science 11 2%
Other 65 11%
Unknown 128 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 202. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2022.
All research outputs
#182,920
of 24,460,744 outputs
Outputs from Science
#5,303
of 79,784 outputs
Outputs of similar age
#3,434
of 304,205 outputs
Outputs of similar age from Science
#107
of 1,088 outputs
Altmetric has tracked 24,460,744 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 79,784 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 64.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,205 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,088 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.