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The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity

Overview of attention for article published in Diabetes, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
4 tweeters
facebook
2 Facebook pages
wikipedia
1 Wikipedia page

Citations

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30 Dimensions

Readers on

mendeley
56 Mendeley
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Title
The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
Published in
Diabetes, April 2012
DOI 10.2337/db11-1511
Pubmed ID
Authors

Sherley Visinoni, Nurul Fathiah Izzati Khalid, Christos N. Joannides, Arthur Shulkes, Mildred Yim, Jon Whitehead, Tony Tiganis, Benjamin J. Lamont, Jenny M. Favaloro, Joseph Proietto, Sofianos Andrikopoulos, Barbara C. Fam

Abstract

Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only to regulate glucose or has other metabolic consequences is not clear; therefore, the aim of this study was to determine the importance of liver FBPase in body weight regulation. To this end we performed comprehensive physiologic and biochemical assessments of energy balance in liver-specific transgenic FBPase mice and negative control littermates of both sexes. In addition, hepatic branch vagotomies and pharmacologic inhibition studies were performed to confirm the role of FBPase. Compared with negative littermates, liver-specific FBPase transgenic mice had 50% less adiposity and ate 15% less food but did not have altered energy expenditure. The reduced food consumption was associated with increased circulating leptin and cholecystokinin, elevated fatty acid oxidation, and 3-β-hydroxybutyrate ketone levels, and reduced appetite-stimulating neuropeptides, neuropeptide Y and Agouti-related peptide. Hepatic branch vagotomy and direct pharmacologic inhibition of FBPase in transgenic mice both returned food intake and body weight to the negative littermates. This is the first study to identify liver FBPase as a previously unknown regulator of appetite and adiposity and describes a novel process by which the liver participates in body weight regulation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Mexico 1 2%
Spain 1 2%
Chile 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 20%
Student > Ph. D. Student 10 18%
Student > Master 7 13%
Researcher 5 9%
Student > Doctoral Student 4 7%
Other 10 18%
Unknown 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 39%
Medicine and Dentistry 10 18%
Biochemistry, Genetics and Molecular Biology 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Nursing and Health Professions 1 2%
Other 5 9%
Unknown 10 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2014.
All research outputs
#2,055,545
of 12,472,966 outputs
Outputs from Diabetes
#1,282
of 6,911 outputs
Outputs of similar age
#18,549
of 117,731 outputs
Outputs of similar age from Diabetes
#11
of 72 outputs
Altmetric has tracked 12,472,966 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,911 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.