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Feasibility of automated proton therapy plan adaptation for head and neck tumors using cone beam CT images

Overview of attention for article published in Radiation Oncology, April 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

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4 tweeters

Citations

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22 Dimensions

Readers on

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63 Mendeley
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Title
Feasibility of automated proton therapy plan adaptation for head and neck tumors using cone beam CT images
Published in
Radiation Oncology, April 2016
DOI 10.1186/s13014-016-0641-7
Pubmed ID
Authors

Christopher Kurz, Reinoud Nijhuis, Michael Reiner, Ute Ganswindt, Christian Thieke, Claus Belka, Katia Parodi, Guillaume Landry

Abstract

Intensity modulated proton therapy (IMPT) of head and neck (H&N) tumors may benefit from plan adaptation to correct for the dose perturbations caused by weight loss and tumor volume changes observed in these patients. As cone beam CT (CBCT) is increasingly considered in proton therapy, it may be possible to use available CBCT images following intensity correction for plan adaptation. This is the first study exploring IMPT plan adaptation on CBCT images corrected and delineated by deformable image registration of the planning CT (pCT) to the CBCT, yielding a virtual CT (vCT). A Morphons algorithm was used to deform the pCTs and corresponding delineations of 9 H&N cancer patients to a weekly CBCT acquired within ±3 days of a control replanning CT scan (rpCT). The IMPT treatment plans were adapted using the vCT and the adapted and original plans were recalculated on the rpCT for dose/volume parameter evaluation of the impact of adaptation. On the rpCT, the adapted plans were equivalent to the original plans in terms of target volumes D 95 and V 95, but showed a significant reduction of D 2 in these volumes. OAR doses were mostly equivalent or reduced. In particular, the adapted plans did not reduce parotid gland D mean, but the dose to the optical system. For three patients the spinal cord or brain stem received higher, though well below tolerance, maximum dose. Subsequent tightening of the treatment planning constraints for these OARs on new vCT-adapted plans did not degrade target coverage and yielded pCT equivalent plans on the vCT. An offline automated procedure to generate an adapted IMPT plan on CBCT images was developed and investigated. When evaluating the adapted plan on a control rpCT we observed reduced D 2 in target volumes as major improvement. OAR sparing was only partially improved by the procedure. Despite potential limitations in the accuracy of the vCT approach, an improved quality of the adapted plans could be achieved.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 29%
Researcher 13 21%
Student > Master 8 13%
Other 7 11%
Student > Bachelor 4 6%
Other 10 16%
Unknown 3 5%
Readers by discipline Count As %
Physics and Astronomy 20 32%
Medicine and Dentistry 20 32%
Computer Science 5 8%
Engineering 5 8%
Nursing and Health Professions 2 3%
Other 1 2%
Unknown 10 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#3,501,598
of 7,644,999 outputs
Outputs from Radiation Oncology
#411
of 1,048 outputs
Outputs of similar age
#121,622
of 266,475 outputs
Outputs of similar age from Radiation Oncology
#13
of 41 outputs
Altmetric has tracked 7,644,999 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 1,048 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,475 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.