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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior
|
|---|---|
| Published in |
Genetic Vaccines and Therapy, April 2012
|
| DOI | 10.1186/1479-0556-10-2 |
| Pubmed ID | |
| Authors |
Flávia Helena da Silva, Vanessa Gonçalves Pereira, Eduardo G Yasumura, Lígia Zacchi Tenório, Leonardo Pinto de Carvalho, Bianca Cristina Garcia Lisboa, Priscila Keiko Matsumoto, Roberta Sessa Stilhano, Vivian Y Samoto, Bruno Frederico Aguilar Calegare, Letícia de Campos Brandão, Vânia D’Almeida, Thaís RM Filippo, Marimélia Porcionatto, Leny Toma, Helena Bonciani Nader, Valderez Bastos Valero, Melissa Camassola, Nance Beyer Nardi, Sang Won Han |
| Abstract |
Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate. While the currently available therapies have good systemic effects, they only minimally affect the neurodegenerative process. Based on the neuroprotective and tissue regenerative properties of mesenchymal stem cells (MSCs), we hypothesized that the administration of MSCs transduced with a murine leukemia virus (MLV) vector expressing IDUA to IDUA KO mouse brains could reduce GAG deposition in the brain and, as a result, improve neurofunctionality, as measured by exploratory activity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Researcher | 6 | 20% |
| Professor | 4 | 13% |
| Other | 4 | 13% |
| Student > Bachelor | 3 | 10% |
| Other | 6 | 20% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 33% |
| Agricultural and Biological Sciences | 8 | 27% |
| Medicine and Dentistry | 3 | 10% |
| Immunology and Microbiology | 2 | 7% |
| Environmental Science | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2012.
All research outputs
#18,305,773
of 22,664,644 outputs
Outputs from Genetic Vaccines and Therapy
#40
of 43 outputs
Outputs of similar age
#124,580
of 161,584 outputs
Outputs of similar age from Genetic Vaccines and Therapy
#1
of 1 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 43 research outputs from this source. They receive a mean Attention Score of 4.5. This one scored the same or higher as 3 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,584 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them