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Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization

Overview of attention for article published in Arthritis Research & Therapy, April 2012
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Title
Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization
Published in
Arthritis Research & Therapy, April 2012
DOI 10.1186/ar3807
Pubmed ID
Authors

Beate Böhm, Harald Burkhardt, Steffen Uebe, Maria Apel, Frank Behrens, André Reis, Ulrike Hüffmeier

Abstract

In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities. The risk allele of p.Asp10Asn (rs33980500) proved to be most significantly associated and to encode a mutant protein with an almost completely disrupted binding property to TRAF6, supporting its impact as a main disease-causing variant and modulator of IL-17 signaling.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Ph. D. Student 4 18%
Student > Master 3 14%
Student > Doctoral Student 2 9%
Other 2 9%
Other 1 5%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Agricultural and Biological Sciences 7 32%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Psychology 1 5%
Other 1 5%
Unknown 4 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2012.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Arthritis Research & Therapy
#2,539
of 3,382 outputs
Outputs of similar age
#114,015
of 174,332 outputs
Outputs of similar age from Arthritis Research & Therapy
#44
of 67 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,382 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,332 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.