A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

@shadwell_NTT @Cambridge_Uni @EllieRaffan @IMS_MRL @PDN_Cambridge This is our 2016 paper: https://t.co/b3WCOVxWhl This is our latest paper: https://t.co/kTnI24SapZ @shadwell_NTT

I'm getting side-tracked by interesting, although not entirely relevant, #research today. 😆 #appetite #appetiteregulation #pets A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs ... https:

RT @MitchRoitman: @ZigmanLab @jamiedroitman @thewilliamslab @AbizaidAlfie While I have long suspected that Bear suffers from poor beta-MSH…

@ZigmanLab @jamiedroitman @thewilliamslab @AbizaidAlfie While I have long suspected that Bear suffers from poor beta-MSH production (https://t.co/C4s3FKCcr3), @ZigmanLab's "The Leap2 Conspiracy" has rocked my world.

RT @thewilliamslab: @NutritionNerd Love this one by @GilesYeo @StephenORahilly about "flabradors"! https://t.co/arpFigkjf5 https://t.co/k…

RT @thewilliamslab: @NutritionNerd Love this one by @GilesYeo @StephenORahilly about "flabradors"! https://t.co/arpFigkjf5 https://t.co/k…

RT @thewilliamslab: @NutritionNerd Love this one by @GilesYeo @StephenORahilly about "flabradors"! https://t.co/arpFigkjf5 https://t.co/k…

@NutritionNerd Love this one by @GilesYeo @StephenORahilly about "flabradors"! https://t.co/arpFigkjf5 https://t.co/kWaUakrpQG

RT @vass_vassiliou: Sunday new fact... Who loves dogs? Some Labradors have a genetic predisposition to getting fat! (just like human lept…

RT @vass_vassiliou: Sunday new fact... Who loves dogs? Some Labradors have a genetic predisposition to getting fat! (just like human lept…

RT @vass_vassiliou: Sunday new fact... Who loves dogs? Some Labradors have a genetic predisposition to getting fat! (just like human lept…

Sunday new fact... Who loves dogs? Some Labradors have a genetic predisposition to getting fat! (just like human leptin). Did't know this until today! Reference here: https://t.co/aYPdX5U1jV How much #whycmr will you learn at #SCMR23? Come 2 find out

The phenotype is so strong there is no need to genotype this guy https://t.co/hhA740AFFu https://t.co/8NGp7lw55H

@greizbianbaam @HinataFischkopp @jadekompendium https://t.co/OyzDo8pLwJ https://t.co/9fSgxZCtuB

@MikaelNiku @MinnaRautio1 @Kiili Tarkoitatko tätä julkaisua: https://t.co/cf1qoGxsHO

The @GOdogsProject team identified a POMC gene deletion in Labrador and flat-coated retriever breeds. Present in >10% of the Labrador population! In affected dogs this is associated with increased body weight, #adiposity and food motivation. 🐶https://t.

RT @DTScholars: Well done Benji! 👏 Did you know that researchers from @Cambridge_Uni have identified a genetic variant which may help expla…

Well done Benji! 👏 Did you know that researchers from @Cambridge_Uni have identified a genetic variant which may help explain why Labradors are prone to obesity? 🧬You can check out the #OpenAccess study (co-funded by @DogsTrust) here 👇 https://t.co/IFeoVV0

Day 23 of #AnimalAdvent is Kruk🎁 Kruk is a fussy eater, unlike many Labradors 🥧 Research from @Cambridge_Uni recently identified a gene variant associated with weight & appetite in Labradors 🐕 potentially making them more obese prone than other breeds👉

@marilocorrero Es que en su sistema, los labradores tienen una secuencia de ADN que les impide sentirse saciados. Por eso siempre tienen hambre. Otra maravillosa consecuencia de la cría de razas... modo ironía on. https://t.co/Nw9zwlnhIx

RT @KarinaRatiner: OMG. It just dawned on me that my dog has a mutation. I guess it was meant to be. Anyway, is it too early for time-restr…

RT @KarinaRatiner: OMG. It just dawned on me that my dog has a mutation. I guess it was meant to be. Anyway, is it too early for time-restr…

RT @KarinaRatiner: OMG. It just dawned on me that my dog has a mutation. I guess it was meant to be. Anyway, is it too early for time-restr…

RT @KarinaRatiner: OMG. It just dawned on me that my dog has a mutation. I guess it was meant to be. Anyway, is it too early for time-restr…

OMG. It just dawned on me that my dog has a mutation. I guess it was meant to be. Anyway, is it too early for time-restricted feeding? 🐶♥️🍽#AskingForAFriend #goldenretriever #chrononutrition https://t.co/iirW9raoFO https://t.co/qIcJG8CMzG

@ethanjweiss I’m reminded of this twice daily X 2 https://t.co/babnpr2BOz

The @GOdogsProject team identified a gene deletion in Labrador and flat-coated retriever breeds. In affected dogs this is associated with increased body weight, adiposity and food motivation https://t.co/8OKKIN8Au1 🧵 4/6 https://t.co/ijzA3ISAkv

@MKBHolt @GilesYeo I ❤ the Labrador vs Flabrador story, told by a wonderful storyteller! https://t.co/zmoFv1eKLM

@GilesPalaeoLab I am guessing you know about this... https://t.co/D5Gv0T2duQ. We call our labradoodle a poobrador as she has all the undesirable traits. 😂

@StephenORahilly @ESRogs Well now I'm embarrassed because that paper was also from @StephenORahilly group 😁 https://t.co/5kj7jghT2j

@ultimatellama @Kika_GuideDog Definitely! Lucy could eat her dinner in less than 20 s. Labs often have a mutation in a pathway that controls appetite and it's more common in assistance dogs maybe because food motivation makes them more trainable https://t.

RT @timfrayling: but this is comfortably the best dog genetics story :-) - a defect to the same gene that causes severe obesity in kids, ma…

My favourite is this one, where a direct to consumer testing company reported a dog 'would probably be great for quick movements like boxing and basketball, and that she has the cardiac output for long endurance bike rides' https://t.co/Xt3gTV5sz1

but this is comfortably the best dog genetics story :-) - a defect to the same gene that causes severe obesity in kids, makes for great guide dogs: https://t.co/7j5AMrO9EU

@Gc8Mercedes This is a cool paper!

@LauredelaVega Laure, have a look at this papers from colleagues few years ago....chocolate labs are always humgry. https://t.co/uuTt5ST7Sh

A genetic basis for why my lab eats everything! https://t.co/HxCbtnC0EX

These lads eat anything. https://t.co/FgmA0QfJnx

@bealelab @FlossieTeacake Absolutely! Labradors are lovely too, but have appetite issues owing to a deletion in the POMC gene... https://t.co/ugaMsv51pq

i've spent wayy too much time (instead of studying) thinking about how some labradors are genetically prone to be obese and they can't stop eating when food is put in front of them https://t.co/ZC1BFlyKyB

@knsstxs @KlutheScience https://t.co/oaZrQtMJU1

https://t.co/cvtgWQdRNK whats good for the goose is good for the gander https://t.co/cvtgWQdRNK

@lepinkainen @qikipedia https://t.co/5HdI3bHJzj

@Eva_Romera Es por una mutación en MC4R y el gen agoutí. Provoca que haya poca eumelanina y antagonismo para la saciedad. https://t.co/t2Of6K3frN

@tednaiman Every feline is different. Every canine is different, too. https://t.co/asNmDTo7Up Every human.... I think you get the gist!

@MorganPfiffner @whsource May also be confounded by the fact that this breed in particular is vry prone to appetite & satiety issues genetically? I've had several breeds of dogs; some self-regulate very well (ie leave food in the bowl) others can eat t

@Don_lyall @GDB_official I also remember seeing Sir O'Rahilly present this in SD in 2014 https://t.co/gO2dJZb85V

RT @darrenlogan: Raffan: About 25% of Labradors have a inactivating mutation in POMC, a key appetite regulating hormone. https://t.co/b7m6W…

There you go, Labradors have more food motivation and are prone to obesity due to a gene mutation. The genetic... https://t.co/Q01VaENgPp

RT @darrenlogan: Raffan: About 25% of Labradors have a inactivating mutation in POMC, a key appetite regulating hormone. https://t.co/b7m6W…

RT @darrenlogan: Raffan: About 25% of Labradors have a inactivating mutation in POMC, a key appetite regulating hormone. https://t.co/b7m6W…

Raffan: About 25% of Labradors have a inactivating mutation in POMC, a key appetite regulating hormone. https://t.co/b7m6WRwV7G #ECRO2017

RT @kdinbburg: A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retrievers https://t.co/…

The Genetics of Pooched-Out Pooches: Obesity #gene candidate found in Labrador Dogs https://t.co/hCLbmC5bGp #OA: https://t.co/AHGPVRA8CS https://t.co/iTXngQw41b

Nice article by @rkhamsi on a 14 bp deletion in POMC that increases appetite in Labrador retrievers. https://t.co/VAMi4R7mOK https://t.co/2e0zMk0H7f

RT @sketchscience: Nice paper! @EllieRaffan @GOdogsProject @Cell_Metabolism https://t.co/nnZW5Dq8aS https://t.co/HRWDYRGKrZ

RT @sketchscience: Nice paper! @EllieRaffan @GOdogsProject @Cell_Metabolism https://t.co/nnZW5Dq8aS https://t.co/HRWDYRGKrZ

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @GOdogsProject: @GOdogsProject made the #altmetrictop100 @GilesYeo @odonovcj @TheFatVet https://t.co/x6aU3np4U5 via @altmetric https:…

RT @PaulBrowne55: Well done @GilesYeo and the rest of the @GOdogsProject team! #altmetrictop100 https://t.co/VUTZAdVwmg

RT @GOdogsProject: @GOdogsProject made the #altmetrictop100 @GilesYeo @odonovcj @TheFatVet https://t.co/x6aU3np4U5 via @altmetric https:…

RT @PaulBrowne55: Well done @GilesYeo and the rest of the @GOdogsProject team! #altmetrictop100 https://t.co/VUTZAdVwmg

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

The POMC route to PORK…. In labs. Ht @TheFatVet https://t.co/x0LX8UvAiV

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

@GOdogsProject made the #altmetrictop100 @GilesYeo @odonovcj @TheFatVet https://t.co/x6aU3np4U5 via @altmetric https://t.co/ee6Jg2xlsz

RT @MRC_Epid: Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t…

Well done @GilesYeo and the rest of the @GOdogsProject team! #altmetrictop100 https://t.co/VUTZAdVwmg

Congratulations to @GOdogsProject on making the 2016 #altmetrictop100 for paper on appetite and weight in Labradors https://t.co/gu2Yjvxm6s! https://t.co/27hJA7jjZB

@spwells @razibkhan Hopefully results in neat insights like the Labrador POMC study https://t.co/KWAhINdbcO

@CamVetSchool Looking forward to it! But if anyone is interested in why Labs are prone to obesity, read our paper https://t.co/9ELNMKBrE7

@garytaubes or maybe it's just over breeding? https://t.co/okQ5vhozFp

RT @timfrayling: @BioMickWatson The most fascinating dog genome study? Are guide dogs so trainable because they're hungry? : https://t.co/N…

RT @timfrayling: @BioMickWatson The most fascinating dog genome study? Are guide dogs so trainable because they're hungry? : https://t.co/N…

@BioMickWatson The most fascinating dog genome study? Are guide dogs so trainable because they're hungry? : https://t.co/NIlFfWtKMP #GS2016

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs https://t.co/u4gC2ru99Y

@GOdogsProject 3/3 And how might being a Lab with a POMC mutation alter your MRI response to a treat? https://t.co/BVDWoF2MvK

RT @F1000: We’re gonna need a bigger collar: genetics behind the tendency of Labradors to become obese https://t.co/YbzEtPaHxq https://t.co…

We’re gonna need a bigger collar: genetics behind the tendency of Labradors to become obese https://t.co/YbzEtPaHxq https://t.co/9YRQeglvQ4

RT @F1000: We’re gonna need a bigger collar: genetics behind the tendency of Labradors to become obese https://t.co/YbzEtPaHxq https://t.co…

RT @F1000: We’re gonna need a bigger collar: genetics behind the tendency of Labradors to become obese https://t.co/YbzEtPaHxq https://t.co…

We’re gonna need a bigger collar: genetics behind the tendency of Labradors to become obese https://t.co/YbzEtPaHxq https://t.co/rfTUur8yKY

RT @GOdogsProject: Our GOdogs article was recommended on F1000Prime (@F1000) https://t.co/74TbMXSaJk Thanks @LoraHeisler!

Our GOdogs article was recommended on F1000Prime (@F1000) https://t.co/74TbMXSaJk Thanks @LoraHeisler!

Obesity-prone labrador retrievers have a deletion in the POMC neuropeptide gene https://t.co/I40YkZdNNV

RT @sketchscience: Nice paper! @EllieRaffan @GOdogsProject @Cell_Metabolism https://t.co/nnZW5Dq8aS https://t.co/HRWDYRGKrZ

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs… https://t.co/jgduXHonFI

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs https://t.co/sp2D8837MB

RT @antlp33: A possible reason why Labrador Retrievers are more prone to obesity https://t.co/7AefsttH70

RT @antlp33: A possible reason why Labrador Retrievers are more prone to obesity https://t.co/7AefsttH70

A possible reason why Labrador Retrievers are more prone to obesity https://t.co/7AefsttH70

Pourquoi les labradors ont-ils toujours faim ? https://t.co/veZwOgNCVD (+ https://t.co/OHoPBDZ46M )

Mutation du gène de la pro-opiomélanocortine et obésité chez le labrador (Cell Metabolism). https://t.co/NjfrHesBZt https://t.co/79QnUXX7At