Title |
Detection of BK virus in urine from renal transplant subjects by mass spectrometry
|
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Published in |
Clinical Proteomics, April 2012
|
DOI | 10.1186/1559-0275-9-4 |
Pubmed ID | |
Authors |
Rebecca Konietzny, Roman Fischer, Nicola Ternette, Cynthia A Wright, Ben W Turney, Aron Chakera, David Hughes, Benedikt M Kessler, Chris W Pugh |
Abstract |
The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity enables sustained viral replication to occur in urothelial cells, which potentially leads to the development of BKV-associated nephropathy (BKVAN). Current guidelines recommend regular surveillance for BKV reactivation through the detection of infected urothelial cells in urine (decoy cells) or viral nucleic acid in urine or blood. However, these methods have variable sensitivity and cannot routinely distinguish between different viral subtypes. We therefore asked whether mass spectrometry might be able to overcome these limitations and provide an additional non-invasive technique for the surveillance of BKV and identification of recipients at increased risk of BKVAN. |
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Demographic breakdown
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