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Association of serum leptin levels with central arterial stiffness in coronary artery disease patients

Overview of attention for article published in BMC Cardiovascular Disorders, May 2016
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Title
Association of serum leptin levels with central arterial stiffness in coronary artery disease patients
Published in
BMC Cardiovascular Disorders, May 2016
DOI 10.1186/s12872-016-0268-5
Pubmed ID
Authors

Jen-Pi Tsai, Ji-Hung Wang, Mei-Ling Chen, Chiu-Fen Yang, Yu-Chih Chen, Bang-Gee Hsu

Abstract

Serum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients. Fasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and ≤ 10 m/s as low arterial stiffness. Thirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness. Increasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Student > Bachelor 5 17%
Researcher 3 10%
Student > Master 3 10%
Student > Doctoral Student 2 7%
Other 3 10%
Unknown 7 24%
Readers by discipline Count As %
Medicine and Dentistry 10 34%
Biochemistry, Genetics and Molecular Biology 4 14%
Nursing and Health Professions 2 7%
Social Sciences 1 3%
Business, Management and Accounting 1 3%
Other 2 7%
Unknown 9 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#16,382,775
of 24,132,691 outputs
Outputs from BMC Cardiovascular Disorders
#907
of 1,777 outputs
Outputs of similar age
#184,026
of 303,204 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#16
of 38 outputs
Altmetric has tracked 24,132,691 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,777 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 303,204 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.