Title |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis
|
---|---|
Published in |
Parasites & Vectors, May 2016
|
DOI | 10.1186/s13071-016-1540-3 |
Pubmed ID | |
Authors |
Juliana Perrone de Menezes, Elvira M. Saraiva, Bruno da Rocha-Azevedo |
Abstract |
Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 1% |
Peru | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 249 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 19% |
Student > Bachelor | 42 | 17% |
Student > Master | 37 | 15% |
Researcher | 23 | 9% |
Student > Doctoral Student | 21 | 8% |
Other | 32 | 13% |
Unknown | 52 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 22% |
Biochemistry, Genetics and Molecular Biology | 46 | 18% |
Immunology and Microbiology | 33 | 13% |
Medicine and Dentistry | 22 | 9% |
Veterinary Science and Veterinary Medicine | 11 | 4% |
Other | 22 | 9% |
Unknown | 64 | 25% |