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Mendeley readers
Attention Score in Context
| Title |
TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
|
|---|---|
| Published in |
Journal of Leukocyte Biology, May 2016
|
| DOI | 10.1189/jlb.2ri1115-531r |
| Pubmed ID | |
| Authors |
M Obayed Ullah, Matthew J Sweet, Ashley Mansell, Stuart Kellie, Bostjan Kobe |
| Abstract |
Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway in host defense. Indeed, the TRIF pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activation of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound-repair processes. Here, we review our current understanding of the regulatory mechanisms that control TRIF-dependent TLR signaling, the role of the TRIF pathway in different infectious and noninfectious pathologic states, and the potential for manipulating TRIF-dependent TLR signaling for therapeutic benefit. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Unknown | 218 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 18% |
| Student > Bachelor | 38 | 17% |
| Student > Master | 32 | 15% |
| Researcher | 14 | 6% |
| Student > Doctoral Student | 12 | 5% |
| Other | 25 | 11% |
| Unknown | 58 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 24% |
| Immunology and Microbiology | 45 | 21% |
| Agricultural and Biological Sciences | 18 | 8% |
| Medicine and Dentistry | 11 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
| Other | 18 | 8% |
| Unknown | 65 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2023.
All research outputs
#7,364,645
of 25,820,938 outputs
Outputs from Journal of Leukocyte Biology
#1,131
of 4,313 outputs
Outputs of similar age
#97,341
of 316,763 outputs
Outputs of similar age from Journal of Leukocyte Biology
#12
of 49 outputs
Altmetric has tracked 25,820,938 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,313 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,763 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.