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Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library

Overview of attention for article published in BMC Biotechnology, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
patent
5 patents

Citations

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8 Dimensions

Readers on

mendeley
34 Mendeley
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Title
Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library
Published in
BMC Biotechnology, May 2012
DOI 10.1186/1472-6750-12-23
Pubmed ID
Authors

Yonghai Li, Donald L Siegel, Nathalie Scholler, David E Kaplan

Abstract

Glypican-3 (GPC3) is a heparan-sulfate proteoglycan frequently expressed on the cell membrane of malignant hepatocytes in hepatocellular carcinoma. The capacity for screening potential antibodies in vitro using human hepatocellular lines is critical to ensure binding to this highly post-translationally modified glycophosphatidylinositiol-linked protein. We hypothesized that we could utilize a recently described paired display/secretory yeast library to isolate human-derived scFv against glypican-3 for potential diagnostic and/or therapeutic application.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
France 1 3%
Unknown 31 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 38%
Student > Ph. D. Student 10 29%
Professor > Associate Professor 3 9%
Student > Master 3 9%
Other 1 3%
Other 1 3%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 53%
Biochemistry, Genetics and Molecular Biology 3 9%
Chemistry 3 9%
Immunology and Microbiology 2 6%
Medicine and Dentistry 2 6%
Other 3 9%
Unknown 3 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2021.
All research outputs
#4,145,236
of 22,664,644 outputs
Outputs from BMC Biotechnology
#211
of 935 outputs
Outputs of similar age
#28,324
of 163,426 outputs
Outputs of similar age from BMC Biotechnology
#6
of 15 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 935 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.