Title |
Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins
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Published in |
Journal of Biomedical Semantics, May 2016
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DOI | 10.1186/s13326-016-0057-1 |
Pubmed ID | |
Authors |
Masashi Yokochi, Naohiro Kobayashi, Eldon L. Ulrich, Akira R. Kinjo, Takeshi Iwata, Yannis E. Ioannidis, Miron Livny, John L. Markley, Haruki Nakamura, Chojiro Kojima, Toshimichi Fujiwara |
Abstract |
The nuclear magnetic resonance (NMR) spectroscopic data for biological macromolecules archived at the BioMagResBank (BMRB) provide a rich resource of biophysical information at atomic resolution. The NMR data archived in NMR-STAR ASCII format have been implemented in a relational database. However, it is still fairly difficult for users to retrieve data from the NMR-STAR files or the relational database in association with data from other biological databases. To enhance the interoperability of the BMRB database, we present a full conversion of BMRB entries to two standard structured data formats, XML and RDF, as common open representations of the NMR-STAR data. Moreover, a SPARQL endpoint has been deployed. The described case study demonstrates that a simple query of the SPARQL endpoints of the BMRB, UniProt, and Online Mendelian Inheritance in Man (OMIM), can be used in NMR and structure-based analysis of proteins combined with information of single nucleotide polymorphisms (SNPs) and their phenotypes. We have developed BMRB/XML and BMRB/RDF and demonstrate their use in performing a federated SPARQL query linking the BMRB to other databases through standard semantic web technologies. This will facilitate data exchange across diverse information resources. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 8% |
Unknown | 12 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 15% |
Researcher | 2 | 15% |
Other | 1 | 8% |
Student > Master | 1 | 8% |
Student > Bachelor | 1 | 8% |
Other | 2 | 15% |
Unknown | 4 | 31% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 15% |
Social Sciences | 2 | 15% |
Computer Science | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Physics and Astronomy | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 31% |