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Sex differences on solid organ histological characteristics after brain death1

Overview of attention for article published in Acta Cirurgica Brasileira, April 2016
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Title
Sex differences on solid organ histological characteristics after brain death1
Published in
Acta Cirurgica Brasileira, April 2016
DOI 10.1590/s0102-865020160040000009
Pubmed ID
Authors

Raif Restivo Simão, Sueli Gomes Ferreira, Guilherme Konishi Kudo, Roberto Armstrong Junior, Luiz Fernando Ferraz da Silva, Paulina Sannomiya, Ana Cristina Breithaupt-Faloppa, Luiz Felipe Pinho Moreira

Abstract

To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD). Adult Wistar rats were divided into three groups: female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by maximal pupil dilatation, apnea, absence of reflex, and drop of mean arterial pressure. Six hours after BD, histological evaluation was performed in lungs, heart, liver and kidneys, and levels of inflammatory proteins, estrogen, progesterone, and corticosterone were determined in plasma. In the lungs, females presented more leukocyte infiltration compared to males (p<0.01). Ovariectomized female rat lungs were more hemorrhagic compared to other groups (p<0.001). In the heart, females had higher leukocyte infiltration and tissue edema compared to males (p<0.05). In the liver and kidneys, there were no differences among groups. In female group estradiol and progesterone were sharply reduced 6 hours after BD (p<0.001) to values observed in ovariectomized females and males. Corticosterone levels were similar. Sex hormones influence the development of inflammation and the status of organs. The increased inflammation in lungs and heart of female rats might be associated with the acute reduction in female hormones triggered by BD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 22%
Student > Ph. D. Student 3 17%
Student > Master 1 6%
Student > Bachelor 1 6%
Student > Doctoral Student 1 6%
Other 2 11%
Unknown 6 33%
Readers by discipline Count As %
Medicine and Dentistry 6 33%
Sports and Recreations 1 6%
Immunology and Microbiology 1 6%
Social Sciences 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 0 0%
Unknown 8 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2016.
All research outputs
#11,953,429
of 13,482,133 outputs
Outputs from Acta Cirurgica Brasileira
#101
of 138 outputs
Outputs of similar age
#221,679
of 265,071 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#1
of 2 outputs
Altmetric has tracked 13,482,133 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 138 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,071 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them