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Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer

Overview of attention for article published in Gut, May 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

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5 tweeters
facebook
1 Facebook page

Citations

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29 Dimensions

Readers on

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48 Mendeley
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Title
Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer
Published in
Gut, May 2016
DOI 10.1136/gutjnl-2016-311393
Pubmed ID
Authors

Ujjwal M Mahajan, Steffen Teller, Matthias Sendler, Raghavendra Palankar, Cindy van den Brandt, Theresa Schwaiger, Jens-Peter Kühn, Silvia Ribback, Gunnar Glöckl, Matthias Evert, Werner Weitschies, Norbert Hosten, Frank Dombrowski, Mihaela Delcea, Frank-Ulrich Weiss, Markus M Lerch, Julia Mayerle

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and is projected to be the second leading cause of cancer-related death by 2030. Despite extensive knowledge and insights into biological properties and genetic aberrations of PDAC, therapeutic options remain temporary and ineffective. One plausible explanation for the futile response to therapy is an insufficient and non-specific delivery of anticancer drugs to the tumour site. Superparamagnetic iron oxide nanoparticles (SPIONs) coupled with siRNA directed against the cell cycle-specific serine-threonine-kinase, Polo-like kinase-1 (siPLK1-StAv-SPIONs), could serve a dual purpose for delivery of siPLK1 to the tumour and for non-invasive assessment of efficiency of delivery in vivo by imaging the tumour response. siPLK1-StAv-SPIONs were designed and synthesised as theranostics to function via a membrane translocation peptide with added advantage of driving endosomal escape for mediating transportation to the cytoplasm (myristoylated polyarginine peptides) as well as a tumour-selective peptide (EPPT1) to increase intracellular delivery and tumour specificity, respectively. A syngeneic orthotopic as well as an endogenous cancer model was treated biweekly with siPLK1-StAv-SPIONs and tumour growth was monitored by small animal MRI. In vitro and in vivo experiments using a syngeneic orthotopic PDAC model as well as the endogenous LSL-Kras(G12D), LSL-Trp53(R172H), Pdx-1-Cre model revealed significant accumulation of siPLK1-StAv-SPIONs in PDAC, resulting in efficient PLK1 silencing. Tumour-specific silencing of PLK1 halted tumour growth, marked by a decrease in tumour cell proliferation and an increase in apoptosis. Our data suggest siPLK1-StAv-SPIONs with dual specificity residues for tumour targeting and membrane translocation to represent an exciting opportunity for targeted therapy in patients with PDAC.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Researcher 7 15%
Student > Bachelor 7 15%
Student > Doctoral Student 4 8%
Student > Master 4 8%
Other 5 10%
Unknown 12 25%
Readers by discipline Count As %
Medicine and Dentistry 9 19%
Biochemistry, Genetics and Molecular Biology 7 15%
Agricultural and Biological Sciences 6 13%
Engineering 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 7 15%
Unknown 14 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#6,426,944
of 12,361,602 outputs
Outputs from Gut
#3,355
of 4,749 outputs
Outputs of similar age
#101,467
of 270,315 outputs
Outputs of similar age from Gut
#45
of 100 outputs
Altmetric has tracked 12,361,602 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,749 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,315 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.