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A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy

Overview of attention for article published in BMC Medical Genomics, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#46 of 429)
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
31 Mendeley
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Title
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
Published in
BMC Medical Genomics, May 2012
DOI 10.1186/1755-8794-5-16
Pubmed ID
Authors

Robin M Hallett, Robin M Hallett, Gregory Pond, John A Hassell

Abstract

The efficacy of chemotherapy regimens in breast cancer patients is variable and unpredictable. Whether individual patients either achieve long-term remission or suffer recurrence after therapy may be dictated by intrinsic properties of their breast tumors including genetic lesions and consequent aberrant transcriptional programs. Global gene expression profiling provides a powerful tool to identify such tumor-intrinsic transcriptional programs, whose analyses provide insight into the underlying biology of individual patient tumors. For example, multi-gene expression signatures have been identified that can predict the likelihood of disease reccurrence, and thus guide patient prognosis. Whereas such prognostic signatures are being introduced in the clinical setting, similar signatures that predict sensitivity or resistance to chemotherapy are not currently clinically available.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
United States 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 35%
Student > Ph. D. Student 6 19%
Student > Master 4 13%
Student > Bachelor 3 10%
Other 2 6%
Other 5 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 35%
Biochemistry, Genetics and Molecular Biology 6 19%
Medicine and Dentistry 6 19%
Computer Science 4 13%
Psychology 2 6%
Other 0 0%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2013.
All research outputs
#785,983
of 8,035,137 outputs
Outputs from BMC Medical Genomics
#46
of 429 outputs
Outputs of similar age
#8,890
of 94,872 outputs
Outputs of similar age from BMC Medical Genomics
#1
of 14 outputs
Altmetric has tracked 8,035,137 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 429 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,872 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.