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ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1

Overview of attention for article published in Nature Medicine, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
6 tweeters
patent
2 patents

Citations

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81 Dimensions

Readers on

mendeley
103 Mendeley
Title
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1
Published in
Nature Medicine, May 2012
DOI 10.1038/nm.2759
Pubmed ID
Authors

Inbal Avraham-Davidi, Yona Ely, Van N Pham, Daniel Castranova, Moshe Grunspan, Guy Malkinson, Liron Gibbs-Bar, Oded Mayseless, Gabriella Allmog, Brigid Lo, Carmen M Warren, Tom T Chen, Josette Ungos, Kameha Kidd, Kenna Shaw, Ilana Rogachev, Wuzhou Wan, Philip M Murphy, Steven A Farber, Liran Carmel, Gregory S Shelness, M Luisa Iruela-Arispe, Brant M Weinstein, Karina Yaniv

Abstract

Despite the clear major contribution of hyperlipidemia to the prevalence of cardiovascular disease in the developed world, the direct effects of lipoproteins on endothelial cells have remained obscure and are under debate. Here we report a previously uncharacterized mechanism of vessel growth modulation by lipoprotein availability. Using a genetic screen for vascular defects in zebrafish, we initially identified a mutation, stalactite (stl), in the gene encoding microsomal triglyceride transfer protein (mtp), which is involved in the biosynthesis of apolipoprotein B (ApoB)-containing lipoproteins. By manipulating lipoprotein concentrations in zebrafish, we found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle, rather than lipid moieties within ApoB-containing lipoproteins, that is primarily responsible for this effect. Mechanistically, we identified downregulation of vascular endothelial growth factor receptor 1 (VEGFR1), which acts as a decoy receptor for VEGF, as a key mediator of the endothelial response to lipoproteins, and we observed VEGFR1 downregulation in hyperlipidemic mice. These findings may open new avenues for the treatment of lipoprotein-related vascular disorders.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Mexico 1 <1%
Israel 1 <1%
Netherlands 1 <1%
Unknown 97 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 30%
Student > Ph. D. Student 27 26%
Student > Master 16 16%
Unspecified 8 8%
Student > Bachelor 5 5%
Other 16 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 59%
Biochemistry, Genetics and Molecular Biology 17 17%
Medicine and Dentistry 11 11%
Unspecified 8 8%
Engineering 2 2%
Other 4 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2017.
All research outputs
#1,630,852
of 11,910,800 outputs
Outputs from Nature Medicine
#2,828
of 6,263 outputs
Outputs of similar age
#14,042
of 109,394 outputs
Outputs of similar age from Nature Medicine
#70
of 114 outputs
Altmetric has tracked 11,910,800 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,263 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.0. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,394 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.