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Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

Overview of attention for article published in Clinical and Translational Allergy, May 2016
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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8 tweeters
facebook
2 Facebook pages

Citations

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25 Dimensions

Readers on

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55 Mendeley
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Title
Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
Published in
Clinical and Translational Allergy, May 2016
DOI 10.1186/s13601-016-0108-9
Pubmed ID
Authors

Bodo C. Melnik, Swen Malte John, Pedro Carrera-Bastos, Gerd Schmitz

Abstract

Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of atopic diseases. Farm milk intake has been associated with increased demethylation of FOXP3 and increased numbers of regulatory T cells (Tregs). Thus, the questions arose which components of farm milk control the differentiation and function of Tregs, critical T cell subsets that promote tolerance induction and inhibit the development of allergy and autoimmunity. Based on translational research we identified at least six major signalling pathways that could explain milk's biological role controlling stable FoxP3 expression and Treg differentiation: (1) via maintaining appropriate magnitudes of Akt-mTORC1 signalling, (2) via transfer of milk fat-derived long-chain ω-3 fatty acids, (3) via transfer of milk-derived exosomal microRNAs that apparently decrease FOXP3 promoter methylation, (4) via transfer of exosomal transforming growth factor-β, which induces SMAD2/SMAD3-dependent FoxP3 expression, (5) via milk-derived Bifidobacterium and Lactobacillus species that induce interleukin-10 (IL-10)-mediated differentiation of Tregs, and (6) via milk-derived oligosaccharides that serve as selected nutrients for the growth of bifidobacteria in the intestine of the new born infant. Accumulating evidence underlines that milk is a complex signalling and epigenetic imprinting network that promotes stable FoxP3 expression and long-lasting Treg differentiation, crucial postnatal events preventing atopic and autoimmune diseases.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 24%
Student > Master 12 22%
Student > Ph. D. Student 9 16%
Professor 6 11%
Student > Bachelor 4 7%
Other 6 11%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 35%
Medicine and Dentistry 15 27%
Biochemistry, Genetics and Molecular Biology 7 13%
Nursing and Health Professions 2 4%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 4%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2016.
All research outputs
#2,990,196
of 12,021,854 outputs
Outputs from Clinical and Translational Allergy
#196
of 357 outputs
Outputs of similar age
#80,176
of 278,882 outputs
Outputs of similar age from Clinical and Translational Allergy
#5
of 11 outputs
Altmetric has tracked 12,021,854 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 357 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,882 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.