Title |
Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
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Published in |
Cadernos de Saúde Pública, December 2014
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DOI | 10.1590/0102-311x00115813 |
Pubmed ID | |
Authors |
Dilvania Nicoletti, Leilane Droppa Appel, Pedro Siedersberger Neto, Gabriel Waihrich Guimarães, Linjie Zhang |
Abstract |
This systematic review aimed to investigate the association between maternal smoking during pregnancy and birth defects in children. We performed an electronic search of observational studies in the databases ovid MEDLINE (1950 to April 2010), LILACS and SciELO. We included 188 studies with a total of 13,564,914 participants (192,655 cases). Significant positive associations were found between maternal smoking and birth defects in the following body systems: cardiovascular (OR: 1.11; 95%CI: 1.03-1.19), digestive (OR: 1.18; 95%CI: 1.07-1.30), musculoskeletal (OR: 1.27; 95%CI: 1.16-1.39) and face and neck (OR: 1.28; 95%CI: 1.19-1.37). The strength of association between maternal smoking and birth defects measured by the OR (95%CI) is significantly related to the amount of cigarettes smoked daily (χ2 = 12.1; df = 2; p = 0.002). In conclusion, maternal smoking during pregnancy is associated with congenital malformations in children and this association is dose-dependent. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 75 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 15% |
Student > Bachelor | 10 | 13% |
Student > Postgraduate | 7 | 9% |
Student > Ph. D. Student | 6 | 8% |
Researcher | 5 | 7% |
Other | 14 | 19% |
Unknown | 22 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 41% |
Nursing and Health Professions | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Environmental Science | 2 | 3% |
Other | 9 | 12% |
Unknown | 24 | 32% |