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Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4

Overview of attention for article published in BMC Microbiology, January 2012
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Title
Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4
Published in
BMC Microbiology, January 2012
DOI 10.1186/1471-2180-12-15
Pubmed ID
Authors

Mattias Karlsson, Nikolai Scherbak, Gregor Reid, Jana Jass

Abstract

Epithelial cells of the urinary tract recognize pathogenic bacteria through pattern recognition receptors on their surface, such as toll-like receptors (TLRs), and mount an immune response through the activation of the NF-kappaB pathway. Some uropathogenic bacteria can subvert these cellular responses, creating problems with how the host eliminates pathogens. Lactobacillus is a genus of lactic acid bacteria that are part of the microbiota and consist of many probiotic strains, some specifically for urogenital infections. Immunomodulation has emerged as an important mode of action of probiotic and commensal lactobacilli and given the importance of epithelial cells, we evaluated the effect of the urogenital probiotic Lactobacillus rhamnosus GR-1 on epithelial immune activation.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 1%
Kazakhstan 1 1%
Unknown 86 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 18%
Student > Bachelor 16 18%
Researcher 14 16%
Student > Ph. D. Student 9 10%
Student > Doctoral Student 5 6%
Other 15 17%
Unknown 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 27%
Medicine and Dentistry 16 18%
Immunology and Microbiology 11 13%
Biochemistry, Genetics and Molecular Biology 9 10%
Computer Science 1 1%
Other 9 10%
Unknown 18 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2012.
All research outputs
#17,657,116
of 22,665,794 outputs
Outputs from BMC Microbiology
#1,983
of 3,162 outputs
Outputs of similar age
#191,429
of 246,084 outputs
Outputs of similar age from BMC Microbiology
#58
of 73 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,162 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.