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Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology

Overview of attention for article published in Frontiers in Physiology, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
14 news outlets
blogs
1 blog
twitter
23 tweeters

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
126 Mendeley
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Title
Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology
Published in
Frontiers in Physiology, June 2016
DOI 10.3389/fphys.2016.00194
Pubmed ID
Authors

Alison Barry, Owen Cronin, Aisling M. Ryan, Brian Sweeney, Siew M. Yap, Orna O'Toole, Andrew P. Allen, Gerard Clarke, Ken D. O'Halloran, Eric J. Downer

Abstract

Multiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It accounts for functional deterioration and lasting disability among young adults. A body of literature demonstrates that physical activity counteracts fatigue and depression and may improve overall quality of life in MS patients. Furthermore, much data indicates that exercise ameliorates chronic neuroinflammation and its related pathologies by tipping cytokine profiles toward an anti-inflammatory signature. Recent data has focused on the direct impact of exercise training on the innate immune system by targeting toll-like receptors (TLRs), signaling pattern recognition receptors that govern the innate immune response, shedding light on the physiological role of TLRs in health and disease. Indeed, TLRs continue to emerge as players in the neuroinflammatory processes underpinning MS. This review will highlight evidence that physical activity and exercise are potential immunomodulatory therapies, targeting innate signaling mechanism(s) to modulate MS symptom development and progression.

Twitter Demographics

The data shown below were collected from the profiles of 23 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 <1%
Italy 1 <1%
Unknown 124 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 26 21%
Student > Master 20 16%
Student > Ph. D. Student 13 10%
Researcher 12 10%
Student > Postgraduate 9 7%
Other 23 18%
Unknown 23 18%
Readers by discipline Count As %
Medicine and Dentistry 25 20%
Biochemistry, Genetics and Molecular Biology 15 12%
Nursing and Health Professions 13 10%
Neuroscience 12 10%
Sports and Recreations 10 8%
Other 22 17%
Unknown 29 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 125. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2020.
All research outputs
#261,144
of 21,965,357 outputs
Outputs from Frontiers in Physiology
#132
of 12,703 outputs
Outputs of similar age
#5,472
of 282,059 outputs
Outputs of similar age from Frontiers in Physiology
#6
of 153 outputs
Altmetric has tracked 21,965,357 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,703 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,059 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.