Title |
A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci
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Published in |
Epigenetics & Chromatin, May 2012
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DOI | 10.1186/1756-8935-5-6 |
Pubmed ID | |
Authors |
James G D Prendergast, Pin Tong, David C Hay, Susan M Farrington, Colin A M Semple |
Abstract |
Chromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controlling several disease loci. Human genetic variation, DNA methylation, and disease have been intensely studied, uncovering many sites of allele-specific DNA methylation (ASM). However, little is known about the genome-wide occurrence of sites of allele-specific histone modification (ASHM) and their relationship to human disease. The aim of this study was to investigate the extent and characteristics of sites of ASHM in human embryonic stem cells (hESCs). |
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United Kingdom | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Mendeley readers
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France | 1 | 1% |
Norway | 1 | 1% |
United Kingdom | 1 | 1% |
Korea, Republic of | 1 | 1% |
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United States | 1 | 1% |
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Researcher | 23 | 34% |
Student > Master | 11 | 16% |
Student > Ph. D. Student | 10 | 15% |
Student > Bachelor | 5 | 7% |
Professor > Associate Professor | 4 | 6% |
Other | 9 | 13% |
Unknown | 5 | 7% |
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Biochemistry, Genetics and Molecular Biology | 12 | 18% |
Medicine and Dentistry | 6 | 9% |
Neuroscience | 3 | 4% |
Social Sciences | 1 | 1% |
Other | 3 | 4% |
Unknown | 6 | 9% |