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Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death

Overview of attention for article published in Journal of Biological Chemistry, July 2000
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

patent
5 patents

Citations

dimensions_citation
91 Dimensions

Readers on

mendeley
38 Mendeley
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Title
Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death
Published in
Journal of Biological Chemistry, July 2000
DOI 10.1074/jbc.m005214200
Pubmed ID
Authors

Elizabeth J. Coulson, Kate Reid, Manuel Baca, Kylie A. Shipham, Sarah M. Hulett, Trevor J. Kilpatrick, Perry F. Bartlett

Abstract

The cytoplasmic juxtamembrane region of the p75 neurotrophin receptor (p75(NTR)) has been found to be necessary and sufficient to initiate neural cell death. The region was named "Chopper" to distinguish it from CD95-like death domains. A 29-amino acid peptide corresponding to the Chopper region induced caspase- and calpain-mediated death in a variety of neural and non-neural cell types and was not inhibited by signaling through Trk (unlike killing by full-length p75(NTR)). Chopper triggered cell death only when bound to the plasma membrane by a lipid anchor, whereas non-anchored Chopper acted in a dominant-negative manner, blocking p75(NTR)-mediated death both in vitro and in vivo. Removal of the ectodomain of p75(NTR) increased the potency of Chopper activity, suggesting that it regulates the association of Chopper with downstream signaling proteins.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 5%
Spain 1 3%
Unknown 35 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 24%
Professor 8 21%
Researcher 8 21%
Student > Master 3 8%
Student > Bachelor 3 8%
Other 7 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 47%
Neuroscience 7 18%
Biochemistry, Genetics and Molecular Biology 5 13%
Medicine and Dentistry 4 11%
Psychology 2 5%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2014.
All research outputs
#1,848,942
of 11,293,566 outputs
Outputs from Journal of Biological Chemistry
#5,576
of 51,623 outputs
Outputs of similar age
#64,700
of 278,227 outputs
Outputs of similar age from Journal of Biological Chemistry
#56
of 413 outputs
Altmetric has tracked 11,293,566 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,623 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,227 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 413 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.