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Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica Communications, May 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

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1 news outlet
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4 tweeters

Citations

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38 Dimensions

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80 Mendeley
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Title
Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
Published in
Acta Neuropathologica Communications, May 2016
DOI 10.1186/s40478-016-0317-4
Pubmed ID
Authors

Dawn H. W. Lau, Marte Hogseth, Emma C. Phillips, Michael J. O’Neill, Amy M. Pooler, Wendy Noble, Diane P. Hanger

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. In AD, tau becomes abnormally phosphorylated and aggregates to form intracellular deposits. However, the mechanisms by which tau exerts neurotoxicity in disease remain unclear. Recent studies have suggested that the presence of tau at synapses may indicate a role in neuronal signalling, which could be disrupted in pathological conditions. The non-receptor-associated tyrosine kinase fyn is located at the dendrite in neurons, where it was recently shown to interact with tau to stabilise receptor complexes at the post-synaptic density. Fyn also co-localises with tau in a proportion of neurons containing tau tangles in AD and fyn is also a tau kinase. Hence, tau-fyn interactions could play a pathogenic role in AD. Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn. These residues in tau are flanked by numerous phosphorylation sites and therefore we investigated the relationship between fyn and the degree of tau phosphorylation in human post-mortem brain tissue. We found no difference in the amount of fyn present in control and AD brain. Notably, however, there was a significant correlation between fyn and phosphorylated tau at specific phospho-epitopes in control, but not in AD brain. Our results suggest that the pathological mechanisms underlying AD, that result in increased tau phosphorylation, may disrupt the physiological relationship between tau phosphorylation and fyn.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Researcher 12 15%
Student > Bachelor 12 15%
Student > Master 11 14%
Student > Doctoral Student 5 6%
Other 10 13%
Unknown 13 16%
Readers by discipline Count As %
Neuroscience 24 30%
Agricultural and Biological Sciences 17 21%
Biochemistry, Genetics and Molecular Biology 9 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Chemistry 2 3%
Other 9 11%
Unknown 16 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2019.
All research outputs
#1,492,307
of 14,150,306 outputs
Outputs from Acta Neuropathologica Communications
#179
of 778 outputs
Outputs of similar age
#37,222
of 263,523 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 14,150,306 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 778 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,523 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them