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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

Overview of attention for article published in Genome Biology, May 2012
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 X users
patent
1 patent

Citations

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108 Dimensions

Readers on

mendeley
175 Mendeley
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4 CiteULike
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Title
Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
Published in
Genome Biology, May 2012
DOI 10.1186/gb-2012-13-5-r35
Pubmed ID
Authors

Joachim Weischenfeldt, Johannes Waage, Geng Tian, Jing Zhao, Inge Damgaard, Janus Schou Jakobsen, Karsten Kristiansen, Anders Krogh, Jun Wang, Bo T Porse

Abstract

Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicing has not previously been assayed in a global, unbiased manner. Here, we combine mouse genetics and RNA-seq to provide the first in vivo analysis of the global impact of NMD on splicing patterns in two primary mouse tissues ablated for the NMD factor UPF2.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 3%
France 2 1%
Switzerland 1 <1%
Portugal 1 <1%
Australia 1 <1%
Germany 1 <1%
Unknown 163 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 26%
Researcher 43 25%
Student > Master 18 10%
Student > Doctoral Student 9 5%
Professor > Associate Professor 9 5%
Other 29 17%
Unknown 21 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 84 48%
Biochemistry, Genetics and Molecular Biology 41 23%
Medicine and Dentistry 9 5%
Neuroscience 5 3%
Computer Science 4 2%
Other 9 5%
Unknown 23 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2019.
All research outputs
#7,204,326
of 25,371,288 outputs
Outputs from Genome Biology
#3,269
of 4,467 outputs
Outputs of similar age
#48,529
of 177,849 outputs
Outputs of similar age from Genome Biology
#28
of 42 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,849 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.