Title |
MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins
|
---|---|
Published in |
BMC Bioinformatics, May 2012
|
DOI | 10.1186/1471-2105-13-111 |
Pubmed ID | |
Authors |
Lukasz P Kozlowski, Janusz M Bujnicki |
Abstract |
Intrinsically unstructured proteins (IUPs) lack a well-defined three-dimensional structure. Some of them may assume a locally stable structure under specific conditions, e.g. upon interaction with another molecule, while others function in a permanently unstructured state. The discovery of IUPs challenged the traditional protein structure paradigm, which stated that a specific well-defined structure defines the function of the protein. As of December 2011, approximately 60 methods for computational prediction of protein disorder from sequence have been made publicly available. They are based on different approaches, such as utilizing evolutionary information, energy functions, and various statistical and machine learning methods. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 33% |
Poland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 4 | 2% |
United States | 2 | 1% |
United Kingdom | 2 | 1% |
Germany | 1 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Japan | 1 | <1% |
Unknown | 175 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 27% |
Student > Master | 30 | 16% |
Researcher | 27 | 14% |
Student > Bachelor | 17 | 9% |
Student > Doctoral Student | 7 | 4% |
Other | 21 | 11% |
Unknown | 35 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 63 | 34% |
Biochemistry, Genetics and Molecular Biology | 56 | 30% |
Chemistry | 13 | 7% |
Computer Science | 5 | 3% |
Medicine and Dentistry | 3 | 2% |
Other | 10 | 5% |
Unknown | 37 | 20% |