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Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

Overview of attention for article published in Journal of Neuroinflammation, February 2012
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Title
Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
Published in
Journal of Neuroinflammation, February 2012
DOI 10.1186/1742-2094-9-40
Pubmed ID
Authors

Alexander Rodriguez Guerrero, Kenzo Uchida, Hideaki Nakajima, Shuji Watanabe, Masaya Nakamura, William EB Johnson, Hisatoshi Baba

Abstract

Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the classically activated inflammatory macrophages (M1 phenotype), whereas the alternatively activated macrophages (M2 phenotype) are anti-inflammatory. The objective of this study was to clarify the effects of a temporal blockade of IL-6/IL-6 receptor (IL-6R) engagement, using an anti-mouse IL-6R monoclonal antibody (MR16-1), on macrophage activation and the inflammatory response in the acute phase after spinal cord injury (SCI) in mice.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 1%
Italy 1 <1%
Romania 1 <1%
United Kingdom 1 <1%
Unknown 152 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 24%
Researcher 24 15%
Student > Bachelor 16 10%
Student > Master 16 10%
Student > Doctoral Student 15 9%
Other 25 16%
Unknown 25 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 28%
Medicine and Dentistry 39 24%
Neuroscience 16 10%
Biochemistry, Genetics and Molecular Biology 6 4%
Immunology and Microbiology 5 3%
Other 16 10%
Unknown 34 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2012.
All research outputs
#15,243,549
of 22,665,794 outputs
Outputs from Journal of Neuroinflammation
#1,729
of 2,605 outputs
Outputs of similar age
#99,555
of 155,423 outputs
Outputs of similar age from Journal of Neuroinflammation
#21
of 37 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,423 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.