Title |
Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
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Published in |
Journal of Neuroinflammation, February 2012
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DOI | 10.1186/1742-2094-9-40 |
Pubmed ID | |
Authors |
Alexander Rodriguez Guerrero, Kenzo Uchida, Hideaki Nakajima, Shuji Watanabe, Masaya Nakamura, William EB Johnson, Hisatoshi Baba |
Abstract |
Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the classically activated inflammatory macrophages (M1 phenotype), whereas the alternatively activated macrophages (M2 phenotype) are anti-inflammatory. The objective of this study was to clarify the effects of a temporal blockade of IL-6/IL-6 receptor (IL-6R) engagement, using an anti-mouse IL-6R monoclonal antibody (MR16-1), on macrophage activation and the inflammatory response in the acute phase after spinal cord injury (SCI) in mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Germany | 2 | 1% |
Italy | 1 | <1% |
Romania | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 152 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 24% |
Researcher | 24 | 15% |
Student > Bachelor | 16 | 10% |
Student > Master | 16 | 10% |
Student > Doctoral Student | 15 | 9% |
Other | 25 | 16% |
Unknown | 25 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 28% |
Medicine and Dentistry | 39 | 24% |
Neuroscience | 16 | 10% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Immunology and Microbiology | 5 | 3% |
Other | 16 | 10% |
Unknown | 34 | 21% |