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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Overview of attention for article published in Cell, April 2020
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 15,320)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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3435 Dimensions

Readers on

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7039 Mendeley
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Title
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Published in
Cell, April 2020
DOI 10.1016/j.cell.2020.02.052
Pubmed ID
Authors

Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S. Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann

Abstract

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Finally, we show that the sera from convalescent SARS patients cross-neutralized SARS-2-S-driven entry. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and identify a potential target for antiviral intervention.

Twitter Demographics

The data shown below were collected from the profiles of 5,073 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7,039 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7039 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1175 17%
Student > Bachelor 942 13%
Student > Ph. D. Student 917 13%
Student > Master 715 10%
Student > Doctoral Student 395 6%
Other 1465 21%
Unknown 1430 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1412 20%
Medicine and Dentistry 1133 16%
Agricultural and Biological Sciences 625 9%
Immunology and Microbiology 479 7%
Chemistry 280 4%
Other 1289 18%
Unknown 1821 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4467. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2020.
All research outputs
#353
of 16,094,382 outputs
Outputs from Cell
#4
of 15,320 outputs
Outputs of similar age
#57
of 258,326 outputs
Outputs of similar age from Cell
#1
of 144 outputs
Altmetric has tracked 16,094,382 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.