Title |
Bacterial phylogenetic tree construction based on genomic translation stop signals
|
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Published in |
Microbial Informatics and Experimentation, May 2012
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DOI | 10.1186/2042-5783-2-6 |
Pubmed ID | |
Authors |
Lijing Xu, Jimmy Kuo, Jong-Kang Liu, Tit-Yee Wong |
Abstract |
The efficiencies of the stop codons TAA, TAG, and TGA in protein synthesis termination are not the same. These variations could allow many genes to be regulated. There are many similar nucleotide trimers found on the second and third reading-frames of a gene. They are called premature stop codons (PSC). Like stop codons, the PSC in bacterial genomes are also highly bias in terms of their quantities and qualities on the genes. Phylogenetically related species often share a similar PSC profile. We want to know whether the selective forces that influence the stop codons and the PSC usage biases in a genome are related. We also wish to know how strong these trimers in a genome are related to the natural history of the bacterium. Knowing these relations may provide better knowledge in the phylogeny of bacteria |
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