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A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: design and in vitro evaluation

Overview of attention for article published in Drug Development & Industrial Pharmacy, June 2012
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Title
A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: design and in vitro evaluation
Published in
Drug Development & Industrial Pharmacy, June 2012
DOI 10.3109/03639045.2012.694589
Pubmed ID
Authors

Brunella Parodi, Eleonora Russo, Gabriele Caviglioli, Sara Baldassari, Noemi Gaglianone, Anna Maria Schito, Sergio Cafaggi

Abstract

A matrix based on chitosan lactate and poloxamer 407 was evaluated as a delivery system for the vaginal administration of the antifungal drug econazole. The matrix was investigated both containing the pure drug and after introducing microparticles of Eudragit RS 100 containing econazole. Eudragit RS 100 microparticles were prepared using an emulsion-extraction method and dispersed in a solution containing chitosan lactate (2% w/w) and poloxamer 407 (1.7% w/w). The microparticles, obtained with a yield of 64% w/w and an encapsulation efficiency of 42% w/w, had a diameter of less than 2 μm and a drug loading of 13% w/w. The compressed matrices, characterized by DSC, swelling, erosion, release and mucoadhesion studies, had behaviours dependent on the relative amounts of the contained microparticles. The matrix without microparticles (MECN) showed zero-order release kinetics, with a maximum drug-release of 60% w/w, while those containing 50 or 75% w/w microparticles showed a diffusion controlled release up to 8 and 16 h, respectively, and a linear trend after those time intervals, caused by the erosion process, which allowed reaching a drug-release of approximately 100% w/w at 22 h. In in vitro experiments, the matrices were mucoadhesive and active in inhibiting the growth of Candida albicans 796.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 35%
Researcher 4 24%
Student > Ph. D. Student 4 24%
Student > Doctoral Student 1 6%
Unspecified 1 6%
Other 0 0%
Unknown 1 6%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 35%
Chemistry 3 18%
Medicine and Dentistry 2 12%
Nursing and Health Professions 1 6%
Agricultural and Biological Sciences 1 6%
Other 2 12%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2014.
All research outputs
#7,748,590
of 8,939,477 outputs
Outputs from Drug Development & Industrial Pharmacy
#192
of 414 outputs
Outputs of similar age
#80,748
of 96,209 outputs
Outputs of similar age from Drug Development & Industrial Pharmacy
#5
of 8 outputs
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So far Altmetric has tracked 414 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.