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Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase

Overview of attention for article published in BMC Structural Biology, January 2012
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Title
Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase
Published in
BMC Structural Biology, January 2012
DOI 10.1186/1472-6807-12-15
Pubmed ID
Authors

Yuji Ashikawa, Zui Fujimoto, Yusuke Usami, Kengo Inoue, Haruko Noguchi, Hisakazu Yamane, Hideaki Nojiri

Abstract

Dihydroxylation of tandemly linked aromatic carbons in a cis-configuration, catalyzed by multicomponent oxygenase systems known as Rieske nonheme iron oxygenase systems (ROs), often constitute the initial step of aerobic degradation pathways for various aromatic compounds. Because such RO reactions inherently govern whether downstream degradation processes occur, novel oxygenation mechanisms involving oxygenase components of ROs (RO-Os) is of great interest. Despite substantial progress in structural and physicochemical analyses, no consensus exists on the chemical steps in the catalytic cycles of ROs. Thus, determining whether conformational changes at the active site of RO-O occur by substrate and/or oxygen binding is important. Carbazole 1,9a-dioxygenase (CARDO), a RO member consists of catalytic terminal oxygenase (CARDO-O), ferredoxin (CARDO-F), and ferredoxin reductase. We have succeeded in determining the crystal structures of oxidized CARDO-O, oxidized CARDO-F, and both oxidized and reduced forms of the CARDO-O: CARDO-F binary complex.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 32%
Student > Bachelor 7 19%
Student > Doctoral Student 5 14%
Professor > Associate Professor 4 11%
Student > Master 4 11%
Other 5 14%
Readers by discipline Count As %
Chemistry 18 49%
Agricultural and Biological Sciences 11 30%
Biochemistry, Genetics and Molecular Biology 5 14%
Unspecified 2 5%
Sports and Recreations 1 3%
Other 0 0%