RT @StephanHacker2: Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit…
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RT @StephanHacker2: Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit…
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Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit the menin-MLL protein-protein interaction. Might be a record setting number of four azetidines in a highly active compound (compound 14)
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Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity https://t.co/XFJyec4cS0 #nor論文 共有結合型メニン阻害剤。MLLとのPPIを阻害。中身見てないけど、どんな設計だろう。合成も単純ではなさそうだな