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Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae

Overview of attention for article published in BMC Genomics, May 2016
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Title
Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae
Published in
BMC Genomics, May 2016
DOI 10.1186/s12864-016-2735-x
Pubmed ID
Authors

Pieter De Maayer, Don A. Cowan

Abstract

Post-translational glycosylation of the flagellin protein is relatively common among Gram-negative bacteria, and has been linked to several phenotypes, including flagellar biosynthesis and motility, biofilm formation, host immune evasion and manipulation and virulence. However to date, despite extensive physiological and genetic characterization, it has never been reported for the peritrichously flagellate Enterobacteriaceae. Using comparative genomic approaches we analyzed 2,000 representative genomes of Enterobacteriaceae, and show that flagellin glycosylation islands are relatively common and extremely versatile among members of this family. Differences in the G + C content of the FGIs and the rest of the genome and the presence of mobile genetic elements provide evidence of horizontal gene transfer occurring within the FGI loci. These loci therefore encode highly variable flagellin glycan structures, with distinct sugar backbones, heavily substituted with formyl, methyl, acetyl, lipoyl and amino groups. Additionally, an N-lysine methylase, FliB, previously identified only in the enterobacterial pathogen Salmonella enterica, is relatively common among several distinct taxa within the family. These flagellin methylase island loci (FMIs), in contrast to the FGI loci, appear to be stably maintained within these diverse lineages. The prevalence and versatility of flagellin modification loci, both glycosylation and methylation loci, suggests they play important biological roles among the Enterobacteriaceae.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 13%
Student > Ph. D. Student 6 12%
Researcher 4 8%
Lecturer 4 8%
Student > Doctoral Student 4 8%
Other 14 27%
Unknown 13 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 29%
Biochemistry, Genetics and Molecular Biology 14 27%
Veterinary Science and Veterinary Medicine 2 4%
Unspecified 1 2%
Mathematics 1 2%
Other 3 6%
Unknown 16 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2016.
All research outputs
#14,851,946
of 22,873,031 outputs
Outputs from BMC Genomics
#6,145
of 10,664 outputs
Outputs of similar age
#197,888
of 333,293 outputs
Outputs of similar age from BMC Genomics
#124
of 197 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,664 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,293 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.