↓ Skip to main content

Neonatal screening for severe combined immunodeficiency in Brazil

Overview of attention for article published in Jornal de Pediatria, July 2016
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter
facebook
3 Facebook pages

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Neonatal screening for severe combined immunodeficiency in Brazil
Published in
Jornal de Pediatria, July 2016
DOI 10.1016/j.jped.2015.10.006
Pubmed ID
Authors

Marilia Pyles Patto Kanegae, Lucila Akune Barreiros, Juliana Themudo Lessa Mazzucchelli, Sonia Marchezi Hadachi, Laura Maria de Figueiredo Ferreira Guilhoto, Ana Lúcia Acquesta, Isabel Rugue Genov, Silvia Maia Holanda, Regina Sumiko Watanabe Di Gesu, Ana Lucia Goulart, Amélia Miyashiro Nunes dos Santos, Newton Bellesi, Beatriz Tavares Costa-Carvalho, Antonio Condino-Neto

Abstract

To apply, in Brazil, the T-cell receptor excision circles (TRECs) quantification technique using real-time PCR in newborn screening for severe combined immunodeficiency (SCID) and assess the feasibility of implementing it on a large scale in Brazil. 8715 newborn blood samples were collected on paper filter and, after DNA elution, TRECs were quantified by real-time PCR. The cutoff value to determine whether a sample was abnormal was determined by ROC curve analysis, using SSPS. The concentration of TRECs in 8682 samples ranged from 2 to 2181TRECs/μL of blood, with mean and median of 324 and 259TRECs/μL, respectively. Forty-nine (0.56%) samples were below the cutoff (30TRECs/μL) and were reanalyzed. Four (0.05%) samples had abnormal results (between 16 and 29TRECs/μL). Samples from patients previously identified as having SCID or DiGeorge syndrome were used to validate the assay and all of them showed TRECs below the cutoff. Preterm infants had lower levels of TRECs than full-term neonates. The ROC curve showed a cutoff of 26TRECs/μL, with 100% sensitivity for detecting SCID. Using this value, retest and referral rates were 0.43% (37 samples) and 0.03% (3 samples), respectively. The technique is reliable and can be applied on a large scale after the training of technical teams throughout Brazil.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Researcher 3 16%
Other 2 11%
Student > Master 2 11%
Professor 1 5%
Other 2 11%
Unknown 5 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 26%
Medicine and Dentistry 4 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Nursing and Health Professions 1 5%
Economics, Econometrics and Finance 1 5%
Other 1 5%
Unknown 5 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2016.
All research outputs
#7,080,611
of 12,546,249 outputs
Outputs from Jornal de Pediatria
#173
of 419 outputs
Outputs of similar age
#116,546
of 264,478 outputs
Outputs of similar age from Jornal de Pediatria
#8
of 14 outputs
Altmetric has tracked 12,546,249 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 419 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,478 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.