Title |
Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature
|
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Published in |
Virology Journal, May 2016
|
DOI | 10.1186/s12985-016-0540-4 |
Pubmed ID | |
Authors |
David A. Jaques, Spyridoula Bagetakou, Arnaud G. L’Huillier, Andrea Bartoli, Maria-Isabel Vargas, Joel Fluss, Laurent Kaiser |
Abstract |
Herpes simplex virus (HSV) is the most common identified cause of focal encephalitis worldwide. However, postoperative HSV encephalitis (HSVE) is a rare complication of neurosurgical procedures and a significant clinical challenge We describe 3 cases of postoperative HSVE and review all published reports. A total of 23 cases were identified. Clinical heterogeneity represents a diagnostic challenge in the postoperative setting. Cerebral magnetic resonance imaging showed typical findings in a minority of patients only, whereas HSV-specific polymerase chain reaction on the cerebrospinal fluid proved to be a valuable test. The postoperative viral pathophysiology remains a subject of debate. The rate of adverse outcome is high and early antiviral treatment seems to be a strong predictor of clinical outcome. We recommend early empirical treatment for any patient presenting with post-neurosurgical lymphocytic meningo-encephalitis, and prophylactic antiviral treatment for patients with a history of previous HSVE who will undergo a neurosurgical procedure. |
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Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 14% |
Student > Doctoral Student | 8 | 14% |
Student > Bachelor | 7 | 12% |
Other | 4 | 7% |
Student > Master | 3 | 5% |
Other | 8 | 14% |
Unknown | 19 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 27 | 47% |
Agricultural and Biological Sciences | 3 | 5% |
Neuroscience | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 20 | 35% |