RT @thelonevirologi: Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection h…
What is the evidence that pangolins are tolerant of viral infection? Lacking MDA5 imo suggests they'd be super vulnerable to CoV infections and an unlikely reservoir. Yes, immune responses can be pathogenic, but we have them for a reason!
Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection https://t.co/y3IQEpTxsT
Pangolins lack two innate immune RNA sensors, MDA5 and ZBP1, that could activate inflammatory responses against coronaviruses. https://t.co/Tzmo4Fr7Xn
I remember when researchers first started studying virus-host interactions in bats, and now its pangolins. #Pangolins lack IFIH1/MDA5, a cytoplasmic RNA sensor that initiates innate immune defense upon virus infection: https://t.co/Z55lHjyjOo @FrontImmunol
Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection https://t.co/u8khM3iLsp