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The effects of oxidative stress on female reproduction: a review

Overview of attention for article published in Reproductive Biology and Endocrinology, January 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 636)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
6 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
551 Dimensions

Readers on

mendeley
716 Mendeley
citeulike
1 CiteULike
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Title
The effects of oxidative stress on female reproduction: a review
Published in
Reproductive Biology and Endocrinology, January 2012
DOI 10.1186/1477-7827-10-49
Pubmed ID
Authors

Ashok Agarwal, Anamar Aponte-Mellado, Beena J Premkumar, Amani Shaman, Sajal Gupta

Abstract

Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 716 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
Brazil 3 <1%
Turkey 2 <1%
United Kingdom 2 <1%
Italy 2 <1%
Mexico 2 <1%
Australia 1 <1%
Uruguay 1 <1%
Pakistan 1 <1%
Other 5 <1%
Unknown 692 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 145 20%
Student > Ph. D. Student 104 15%
Researcher 97 14%
Student > Bachelor 92 13%
Student > Doctoral Student 46 6%
Other 138 19%
Unknown 94 13%
Readers by discipline Count As %
Medicine and Dentistry 189 26%
Agricultural and Biological Sciences 152 21%
Biochemistry, Genetics and Molecular Biology 91 13%
Nursing and Health Professions 46 6%
Veterinary Science and Veterinary Medicine 19 3%
Other 93 13%
Unknown 126 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2019.
All research outputs
#789,910
of 16,067,572 outputs
Outputs from Reproductive Biology and Endocrinology
#31
of 636 outputs
Outputs of similar age
#5,275
of 127,982 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#1
of 1 outputs
Altmetric has tracked 16,067,572 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 636 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them